trans-Tranilast|70806-55-2|(反-曲尼司特; trans-MK-341; trans-SB 252218)-陌孚医药/Medlife

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trans-Tranilast (Synonyms: 反-曲尼司特; trans-MK-341; trans-SB 252218)

目录号: PL14758 纯度: ≥99%

CAS No. :70806-55-2

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中文名称	trans-Tranilast
中文别名	反-曲尼司特
英文名称	trans-Tranilast
英文别名	trans-Tranilast;2-{[(2E)-3-(3,4-Dimethoxyphenyl)-2-propenoyl]amino}benzoic acid;(3',4'-dimethoxycinnamoyl)-anthranilic acid;(3.4-Dimethoxy-benzal)-anthranilsaeure;(3.4-Dimethoxy-benzyliden)-anthranilsaeure;(E)-2-{[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino}benzoic acid;2-(3,4-dimethoxycinnamoylamino)benzoic acid;2-(3.4-Dimethoxy-benzalamino)-benzoesae;AC1L86AG;N-(3,4-dimethoxybenzylidene)anthranilic acid;NSC405414;N-veratryliden-anthranilic acid;tranilast (N-(3',4'-dimethoxycinnamoyl)anthranilic acid)
Cas No.	70806-55-2
分子式	C₁₈H₁₇NO₅
分子量	327.33
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	trans-Tranilast (trans-MK-341) 是一种抗过敏剂, 用于研究支气管哮喘, 过敏性鼻炎和特应性皮炎。
生物活性	trans-Tranilast (trans-MK-341) is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis. Target: Angiotensin Receptor Tranilast has been approved in Japan and South Korea, since 1982, for the treatment of bronchial asthma, with indications for keloids and hypertrophic scar added in 1993. Tranilast is also used to treat asthma, autoimmune diseases, atopic and fibrotic pathologies, and can also inhibit angiogenesis. The antiproliferative properties of tranilast were found that tranilast elicited an inhibitory effect on fibroblast proliferation in vitro and also suppressed collagen production both in vitro and in vivo . Tranilast also reduced the release of chemical mediators from mast cells and suppressed hypersensitivity reactions. [1] Three-week-old C57Bl/10 and mdx mice received tranilast (~300 mg/kg) in their food for 9 weeks, after which fibrosis was assessed
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. K Ikai , et al. Inhibitory Effect of Tranilast on Prostaglandin D Synthetase. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6.

溶解度数据	In Vitro: DMSO : 100 mg/mL (305.50 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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