Tasosartan|145733-36-4|(WAY-ANA 756)-陌孚医药/Medlife

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Tasosartan (Synonyms: WAY-ANA 756)

目录号: PL14752 纯度: ≥99%

CAS No. :145733-36-4

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中文名称	Tasosartan
中文别名	他索沙坦;2,4-二甲基-8-[[4-[2-(2H-四唑-5-基)苯基]苯基]甲基]-5,6-二氢吡啶并[6,5-d]嘧啶-7-酮;他沙索坦
英文名称	Tasosartan
英文别名	Tasosartan;2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[6,5-d]pyrimidin-7-one;2,4-dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one;2,4-dimethyl-5,6,8-trihydro-8-[[2'-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one;2,4-dimethyl-8-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one;8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl-methyl]-2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one;ANA-756;Verdia;WAY-ANA-756;48G92V856H;Tasosartan (USAN/INN);Tasosartan [USAN:INN:BAN];PubChem24430;GTPL6898;ADXGNEYLLLSOAR-UHFFFAOYSA-N
Cas No.	145733-36-4
分子式	C₂₃H₂₁N₇O
分子量	411.46
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	Tasosartan 是一种长效的血管紧张素 II (AngII) 受体拮抗剂。
生物活性	Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist.
性状	Solid
IC50 & Target[1][2]	Angiotensin II (AngII) receptor
体外研究(In Vitro)	Tasosartan is an orally active nonpeptide AngII antagonist that has demonstrates specific and selective AT1 receptor antagonistic activity in vitro. IC50 for inhibition of specific binding of I-AngII to rat adrenal membrane in the absence of proteins in binding buffer is 1.2±0.6 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Maillard MP, et al. Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54. [2]. Elokdah HM, et al. Novel human metabolites of the angiotensin-II antagonist Tasosartan and their pharmacological effects. Bioorg Med Chem Lett. 2002 Aug 5;12(15):1967-71.

溶解度数据	In Vitro: DMSO : 125 mg/mL (303.80 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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