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ZD 7155(hydrochloride)

目录号: PL14740 纯度: ≥98%

ZD 7155 hydrochloride是血管紧张素II受体1型 (AT1 receptor) 拮抗剂。

CAS No. :146709-78-6

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中文名称	ZD 7155(hydrochloride)
中文别名	ZD 7155盐酸盐;钛酸镧;ZD7155盐酸盐
英文名称	ZD 7155(hydrochloride)
英文别名	1,6-Naphthyridin-2(1H)-one,5,7-diethyl-3,4-dihydro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-,hydrochloride (1:1);1,6-Naphthyridin-2(1H)-one,5,7-diethyl-3,4-dihydro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-...;5,7-diethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl] -1,2,3,4-tetrahydro-1,6-naphthyridin-2-one hydrochloride;ZD 7155 hydrochloride;ZD 7155;5,7-Diethyl-3,4-dihydro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride;ZD7155HCl;5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride;5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE;ZD 7155(hydrochloride);zd7155;NAGGAAHTUXEGFG-UHFFFAOYSA-N;AK394882;B5083;SR-0
Cas No.	146709-78-6
分子式	C₂₆H₂₇ClN₆O
分子量	474.99
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	ZD 7155 hydrochloride是血管紧张素II受体1型 (AT1 receptor) 拮抗剂。

产品详情	ZD 7155 hydrochloride是血管紧张素II受体1型 (AT1 receptor) 拮抗剂。
生物活性	ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
性状	Solid
IC50 & Target[1][2]	Target: AT1 receptor
体内研究(In Vivo)	In conscious SD rats, ZD 7155 and losartan behave as competitive antagonists and the pressor response curve to angiotensin II is shifted to the right. Experiments in conscious SD rats also show that ZD 7155 is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response (240 ng/kg; 10 min infusion). In addition, experiments with conscious rats demonstrate that ZD 7155 could suppress the angiotensin II-induced pressor response for approximately 24 h when ZD 7155 is administered intravenously in a 1.082 μmol/kg bolus dose and angiotensin II is given at 240 ng/kg (in a 10-min infusion). Experiments in conscious SHRs using ZD 7155 (1.082 mumol/kg) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Junggren IL, et al. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J Pharm Pharmacol. 1996 Aug;48(8):829-33.

溶解度数据	In Vitro: DMSO : 250 mg/mL (526.33 mM; Need ultrasonic)H₂O : 4.17 mg/mL (8.78 mM; ultrasonic and warming and heat to 60°C)配制储备液

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[1]. Junggren IL, et al. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J Pharm Pharmacol. 1996 Aug;48(8):829-33.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

ZD 7155(hydrochloride)

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