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| 商品编号 | 规格 | 价格 | 会员价 | 是否有货 | 数量 |
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| PL14748-10mg | 10mg | ¥658.00 | 请登录 |
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| PL14748-50mg | 50mg | ¥1625.00 | 请登录 |
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| PL14748-100mg | 100mg | ¥2425.00 | 请登录 |
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| PL14748-10mM*1mLinDMSO | 10mM*1mLinDMSO | ¥1414.00 | 请登录 |
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| PL14748-1 mL x 10 mM (in DMSO) | ¥723.00 | 请登录 |
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| 中文名称 |
Eprosartan
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|---|---|
| 中文别名 |
依普罗沙坦;依普沙坦;(E)- Α-[[2-丁基-1-[(4-羧基苯基)甲基]-1H-咪唑-5-基]亚甲基]-2-噻吩丙酸;N-苄氧羰基-DL-色氨酸;普沙坦-D4;依普罗沙坦杂质;甲磺酸依普沙坦;依普沙坦-D4;EPROSARTAN 醋酸盐形式
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| 英文名称 |
Eprosartan
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| 英文别名 |
Eprosartan;Eprosartan Mysylate;(E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid;((E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic Acid;(E)- α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-y1]methylene]2-thiophenepropanoic acid;SKF-108566J;Teveten;Eporlosartan;(E)-4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1H-imidazol-1-yl)methyl)benzoic acid;Des[2-(2-thienylMethyl)] Eprosartan-2-carboxylic Acid;Eprosartan-d9;4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid;(E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic acid;Navixen;SKB 108566;Eprosartan-d4;SKF-108566);prop-1-en-1-yl);-1H-imidazol-1-yl)
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| Cas No. |
133040-01-4
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| 分子式 |
C23H24N2O4S
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| 分子量 |
424.51
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| 包装储存 |
Powder -20°C 3 years；In solvent -80°C 6 months
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| 详情描述 |
Eprosartan (SKF-108566J free base) 是一种选择性，竞争性，非肽和具有口服活性的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，可用作降压剂。Eprosartan 结合血管紧张素 II 受体，在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。
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| 产品详情 |
Eprosartan (SKF-108566J free base) 是一种选择性，竞争性，非肽和具有口服活性的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，可用作降压剂。Eprosartan 结合血管紧张素 II 受体，在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。
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| 生物活性 |
Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC 50 s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
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| 性状 |
Solid
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| 体外研究(In Vitro) |
Eprosartan (SKF-108566J) inhibits [I]AII binding to human liver membranes (IC50 of 1.7 nM) and to rat mesenteric artery membranes (IC50 of 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca levels. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
In conscious normotensive rats, i.v. administration of Eprosartan (0.01-0.3 mg/kg) produced dose-dependent parallel shifts in the AII pressor dose-response curve. Administration of Eprosartan (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.). At 10 mg/kg, i.d., significant inhibition of the pressor response to AII was observed for 3 hr. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；In solvent -80°C 6 months
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| ClinicalTrial |
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| 参考文献 |
[1]. R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260(1):175-81.
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| 溶解度数据 |
In Vitro: DMSO : 125 mg/mL (294.46 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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