购物车0
产品总数：60957
| 中文名称 |
Losartan
|
|---|---|
| 中文别名 |
洛沙坦;2-丁基-4-氯-5-(羟甲基)-1-[[2'-(1H-四氮唑-5-)联苯基-4-]甲基]咪唑;氯沙坦;氯沙坦-D9;洛沙坦 标准品;洛沙坦钾;重铬酸咪唑;2-丁基-4-氯-1-[[2'(-(1H-四唑-5-基)[1,1'(-联苯]-4-基]甲基]-1H-咪唑-5-甲醇;科素亚;科索亚;络沙坦;氯沙坦(氯沙坦钾中间体);洛沙坦溶液, 100PPM;2-丁基-4-氯-5-(羟甲基)-1-[[2’-(1H-四氮唑-5-)联苯基-4-]甲基]咪唑钾盐;氯沙坦/2-丁基-4-氯-5-(羟甲基)-1-[[2'-(1H-四氮唑-5-)联苯基-4-]甲基]咪唑
|
| 英文名称 |
Losartan
|
| 英文别名 |
Losartan;DuP-753;Compound 89;dup89;LOS;LOSARTAN ,USP;2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5- methanol;[
""
];Losartan (DuP-753);LosartanC22H23C1N60;2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-methanol;nyl)-4-yl)methyl)-;2-n-butyl-4-chloro-5-hydroxyMethyl-1-[(2'-(1H-tetrazole-5-yl)biph;DUP 89;Lortaan;LOSARTAN POTASSIUM;Hyzaar;Cozaar;Losartan [INN:BAN];Losartan monopotassium salt;C22H23ClN6O;JMS50MPO89;2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol;DuP 753;[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol;2-n-butyl-4-chloro-5-hy;2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole;(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)b
|
| Cas No. |
114798-26-4
|
| 分子式 |
C22H23ClN6O
|
| 分子量 |
422.91
|
| 包装储存 |
Powder -20°C 3 years；4°C 2 years
|
| 产品详情 |
Losartan 是血管紧张素II受体拮抗剂，与血管紧张素II竞争性结合AT1受体，IC50为20 nM。
|
|---|---|
| 生物活性 |
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC 50 of 20 nM.
|
| 性状 |
Solid
|
| IC50 & Target[1][2] |
IC50: 20 nM (angiotensin II)
|
| 体外研究(In Vitro) |
Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM. Losartan (40 μM) affects ISC but prevents the effect of ANGII on ISC . Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone. has not independently confirmed the accuracy of these methods. They are for reference only.
|
| 体内研究(In Vivo) |
Losartan (0.6 g/L, p.o.) -treated Fbn1 mice show a reduction in distal airspace caliber relative to placebo-treated Fbn1 animals. The doses of losartan and propranolol are titrated to achieve comparable hemodynamic effects. Analysis of pSmad2 nuclear staining reveals that losartan antagonizes TGF-β signaling in the aortic wall of Fbn1 mice. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels 100-fold; plasma angiotensinogen levels decreases to 24% of control; and plasma aldosterone levels are unchanged. has not independently confirmed the accuracy of these methods. They are for r
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Powder -20°C 3 years；4°C 2 years
|
| ClinicalTrial |
|
| 参考文献 |
[1]. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12.[2]. Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.[3]. Choi, C.H., et al. Angiotensin II type I receptor and miR-1
|
| 溶解度数据 |
In Vitro: DMSO : ≥ 100 mg/mL (236.46 mM)配制储备液
|
|---|
1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
Copyright © 2025 陌孚医药 All rights reserved 未经授权禁止拷贝本站所有资料，如有违反，将追究法律责任。
沪ICP备2023012080号 | 
沪公网安备31011402010657号
扫码关注公众号
产品使用指南
