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Losartan

(Synonyms: 氯沙坦; DuP-753)

目录号: PL14770 纯度: ≥99%

Losartan 是血管紧张素II受体拮抗剂，与血管紧张素II竞争性结合AT1受体，IC50为20 nM。

CAS No. :114798-26-4

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中文名称	Losartan
中文别名	洛沙坦;2-丁基-4-氯-5-(羟甲基)-1-[[2'-(1H-四氮唑-5-)联苯基-4-]甲基]咪唑;氯沙坦;氯沙坦-D9;洛沙坦标准品;洛沙坦钾;重铬酸咪唑;2-丁基-4-氯-1-[[2'(-(1H-四唑-5-基)[1,1'(-联苯]-4-基]甲基]-1H-咪唑-5-甲醇;科素亚;科索亚;络沙坦;氯沙坦(氯沙坦钾中间体);洛沙坦溶液, 100PPM;2-丁基-4-氯-5-(羟甲基)-1-[[2’-(1H-四氮唑-5-)联苯基-4-]甲基]咪唑钾盐;氯沙坦/2-丁基-4-氯-5-(羟甲基)-1-[[2'-(1H-四氮唑-5-)联苯基-4-]甲基]咪唑
英文名称	Losartan
英文别名	Losartan;DuP-753;Compound 89;dup89;LOS;LOSARTAN ,USP;2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5- methanol;[ "" ];Losartan (DuP-753);LosartanC22H23C1N60;2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-methanol;nyl)-4-yl)methyl)-;2-n-butyl-4-chloro-5-hydroxyMethyl-1-[(2'-(1H-tetrazole-5-yl)biph;DUP 89;Lortaan;LOSARTAN POTASSIUM;Hyzaar;Cozaar;Losartan [INN:BAN];Losartan monopotassium salt;C22H23ClN6O;JMS50MPO89;2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol;DuP 753;[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol;2-n-butyl-4-chloro-5-hy;2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole;(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)b
Cas No.	114798-26-4
分子式	C₂₂H₂₃ClN₆O
分子量	422.91
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Losartan 是血管紧张素II受体拮抗剂，与血管紧张素II竞争性结合AT1受体，IC50为20 nM。

产品详情

Losartan 是血管紧张素II受体拮抗剂，与血管紧张素II竞争性结合AT1受体，IC50为20 nM。

生物活性

Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC 50 of 20 nM.

性状

Solid

IC50 & Target[1][2]

IC50: 20 nM (angiotensin II)

体外研究(In Vitro)

Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM. Losartan (40 μM) affects ISC but prevents the effect of ANGII on ISC . Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Losartan (0.6 g/L, p.o.) -treated Fbn1 mice show a reduction in distal airspace caliber relative to placebo-treated Fbn1 animals. The doses of losartan and propranolol are titrated to achieve comparable hemodynamic effects. Analysis of pSmad2 nuclear staining reveals that losartan antagonizes TGF-β signaling in the aortic wall of Fbn1 mice. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels 100-fold; plasma angiotensinogen levels decreases to 24% of control; and plasma aldosterone levels are unchanged. has not independently confirmed the accuracy of these methods. They are for r

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12.
[2]. Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.
[3]. Choi, C.H., et al. Angiotensin II type I receptor and miR-1

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (236.46 mM)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Losartan

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