Aβ/tau aggregation-IN-1 是一种有效的 Aβ_1-42 β-sheets 形成和 tau 聚集抑制剂。Aβ/tau aggregation-IN-1 对 Aβ_1-42 和 tau 的 K_D 分别为 160 μM 和 337 μM。Aβ/tau aggregation-IN-1 能通过血脑屏障。

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier.

Solid

Kd: 160 μM (Aβ1-42).
Kd: 337 μM (tau)

Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci.
Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ1-42 and tau. The KD value of Aβ/tau aggregation-IN-1 with Aβ1-42 is 160 μM. The KD value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ1-42 and tau through noncovalent interactions. has not independently confirmed the accuracy of these methods. They are for reference only.<

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

[1]. Lv P, et al. Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. Bioorg Med Chem. 2018;26(16):4693-4705.

In Vitro: DMSO : 33.33 mg/mL (67.70 mM; ultrasonic and warming and heat to 60°C)配制储备液