Thiethylperazine dimaleate|1179-69-7|(二马来酸硫乙基哌嗪)-陌孚医药/Medlife

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Thiethylperazine dimaleate (Synonyms: 二马来酸硫乙基哌嗪)

目录号: PL12125 纯度: ≥99%

CAS No. :1179-69-7

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中文名称	Thiethylperazine dimaleate
中文别名	马来酸硫乙拉嗪;马来酸乙巯拉嗪;4-硝基吡啶;吩噻嗪-2-(乙硫基)-10-(3-(4-甲基-1-哌嗪基)丙基)-马来酸(1:2);马来酸乙巯拉嗪 USP标准品;马来酸甲哌硫丙嗪;马来酸硫乙哌丙嗪;二马来酸硫乙基哌嗪
英文名称	Thiethylperazine dimaleate
英文别名	Thiethylperazine Maleate;Thiethylperazine Dimaleate;THIETHYLPERAZINE MALEATE (200 MG);THIETHYLPERAZINE MALEATE, USP STANDARD;2-butenedioate;gs-95;Thiethylperazinbishydrogenmaleat;torecan;torecanbimaleate;torecandimaleate;torecanmaleate;toresten;tresten;Thiethylperazine dimaleate
Cas No.	1179-69-7
分子式	C₂₂H₂₉N₃S₂^.C₄H₄O₄
分子量	515.69
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	Thiethylperazine dimaleate 是一种吩噻嗪衍生物，是一种口服有效的多巴胺 D2 受体和组胺 H1 受体拮抗剂。Thiethylperazine dimaleate 也是一种选择性的 ABCC1 激活剂，可减少小鼠中的淀粉样 β (Aβ) 负荷。Thiethylperazine dimaleate 具有止吐，抗精神病和抗菌作用。
生物活性	Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects.
性状	Solid
IC50 & Target[1][2]	D2 Receptor H1 Receptor
体外研究(In Vitro)	Thiethylperazine could enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days; young APP/PS1 mice) treatment significantly reduces Aβ42 levels in APP/PS1 mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110(5):497-9. [2]. Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121(10):3924-31. [3]. Rahbar M, et al.

溶解度数据	In Vitro: DMSO : 125 mg/mL (197.86 mM; ultrasonic and warming and heat to 60°C)配制储备液

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