Frentizole|26130-02-9|(夫仑替唑)-陌孚医药/Medlife

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Frentizole (Synonyms: 夫仑替唑)

目录号: PL13268 纯度: ≥99%

CAS No. :26130-02-9

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PL13268-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1808.00	请登录

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中文名称	Frentizole
中文别名	夫仑替唑;N-[6-甲氧基苯并[d]噻唑-2-基]-N'-苯基脲
英文名称	Frentizole
英文别名	Urea,N-(6-methoxy-2-benzothiazolyl)-N'-phenyl-;Frentizole;1-(6-methoxy-2-benzothiazolyl)-3-phenylurea;1-(6-methoxybenzo[d]thiazol-2-yl)-3-phenylurea;1-(6-methoxy-benzothiazol-2-yl)-3-phenyl-urea;Compound 53616;DSSTox_CID_26279;DSSTox_GSID_46279;DSSTox_RID_81505;Frentizol;N-[6-Methoxybenzo[d]thiazol-2-yl]-N'-phenylurea
Cas No.	26130-02-9
分子式	C₁₅H₁₃N₃O₂S
分子量	299.35
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Frentizole, FDA 批准的免疫抑制剂，是 Aβ-ABAD (binding alcohol dehydrogenase) 相互作用抑制剂，IC₅₀ 值为 200 μM。Frentizole 可用于类风湿性关节炎和系统性红斑狼疮等相关疾病的研究。
生物活性	Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC 50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus.
性状	Solid
体外研究(In Vitro)	Frentizole (500 ng/mL, 48 hours) is effective in inhibiting thymidine incorporation into DNA when adds to lymphocyte cultures alongside mitogens, and significantly inhibits the response to concanavalin A by 58% in a dose-dependent manner in lymphocytes extracted from mice peritoneal cavity. Frentizole (62.5 ng/mL) can effectively inhibit uridine incorporation and the inhibition of uridine incorporation is independent of the phytochemical used. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Frentizole (8.2 or 79.9 mg/kg/day for young mice in animal feedings, 52 weeks) can extend the life span of NZB/NZW mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NZB/NZW
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Meisel AD, et al. Effect of frentizole on mitogen-induced blastogenesis in human lymphocytes. J Immunopharmacol. 1979;1(4):483-95. [2]. Walker SE, et al. Prolonged lifespans in female NZB/NZW mice treated with the experimental immunoregulatory drug frentizole. Arthritis Rheum. 1982 Nov;25(11):1291-7.

溶解度数据	In Vitro: DMSO : 12.5 mg/mL (41.76 mM; Need ultrasonic)配制储备液

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