Anle138b 是一种低聚物聚集抑 (oligomeric aggregation ) 调节剂，可阻断朊病毒蛋白 (PrPSc) 和 α-突触核蛋白 (α-syn) 病理性聚集的形成。Anle138b 在体内强烈抑制低聚物积累、神经元变性和疾病进展。Anle138b 毒性低，口服生物利用度高，血脑屏障通透性好。Anle138b 阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。

Anle138b, an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Anle138b strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Anle138b has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

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Oligomeric aggregates are presumed to be the key neurotoxic agent. Anle138b blocksthe formation of pathological aggregates of prion protein and of α-synuclein, which is deposited in Parkinson’s disease and other synucleinopathies such as dementia with Lewy bodies and multiple system atrophy. Anle138b strongly inhibits all prion strains tested including BSE-derived and human prions. Anle138b shows structure-dependent binding to pathological aggregates and strongly inhibits formation of pathological oligomers both for prion protein and α-synuclein. has not independently confirmed the accuracy of these methods. They are for reference only.

Anle138b shows structure-dependent binding to pathological aggregates and strongly inhibits formation of pathological oligomers in vitro and in vivo both for prion protein and α-synuclein.
Anle138b (0.6-2 g/kg; p.o.) modulates α‐synuclein oligomerization. has not independently confirmed the accuracy of these methods. They are for reference only.

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Powder -20°C 3 years；4°C 2 years

[1]. Wagner J, et al. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinsons disease. Acta Neuropathol. 2013 Jun;125(6):795-813.
[2]. Martinez Hernandez A, et al. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Mol Med. 2018;10(1):32-47.

In Vitro: DMSO : ≥ 50 mg/mL (145.70 mM)配制储备液