Thiethylperazine|1420-55-9|-陌孚医药/Medlife

您当前的位置：

Thiethylperazine

目录号: PL12132 纯度: ≥99%

CAS No. :1420-55-9

商品编号	规格	价格	会员价
PL12132-5mg	5mg	¥1607.00	请登录
PL12132-10mg	10mg	¥2410.00	请登录
PL12132-50mg	50mg	¥7232.00	请登录
PL12132-100mg	100mg	¥11090.00	请登录
PL12132-200mg	200mg	询价	询价
PL12132-500mg	500mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Thiethylperazine
中文别名	乙巯拉嗪;乙巯匹拉嗪;硫乙哌丙嗪;硫乙拉嗪;吐来抗
英文名称	Thiethylperazine
英文别名	thiethylperazine;2-ethylthio-10-(3-(4-methylpiperazin-1-yl)propyl)phenothiazine;Ethylthioperazine.;thietylperazine;Tietylperazine;Torecane;2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;2-(Ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine;Thiethylperazine
Cas No.	1420-55-9
分子式	C₂₂H₂₉N₃S₂
分子量	399.62
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	Thiethylperazine 是一种吩噻嗪衍生物，是一种口服有效的多巴胺 D2 受体和组胺 H1 受体拮抗剂。Thiethylperazine 也是一种选择性的 ABCC1 激活剂，可减少小鼠中的淀粉样 β (Aβ) 负荷。Thiethylperazine 具有止吐，抗精神病和抗菌作用。
生物活性	Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.
性状	Solid
IC50 & Target[1][2]	D2 Receptor H1 Receptor
体外研究(In Vitro)	Thiethylperazine can enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110(5):497-9. [2]. Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121(10):3924-31. [3]. Rahbar M, et al.

溶解度数据	In Vitro: DMSO : 100 mg/mL (250.24 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation