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Thioflavin T

(Synonyms: 硫黄素T; Basic Yellow 1)

目录号: PL13147 纯度: ≥98%

Thioflavin T 是一种阳离子 Benzothiazole 染料，在组织切片中与淀粉样蛋白结合后荧光强度增强。

CAS No. :2390-54-7

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PL13147-10mM*1mLinDMSO	10mM*1mLinDMSO	¥884.00	请登录

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中文名称	Thioflavin T
中文别名	硫黄素T;碱性黄1;硫代磺素T;氯化2-[4-(二甲氨基)苯基]-3,6-二甲基苯并噻唑翁;硫代黄色素 T;盐基嫩黄;2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物;Basic Yellow 1 硫黄素T;硫代黄素T;氯化2-[4-(二甲氨基)苯基]-3,5-二甲基苯并噻唑翁;2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑氯化物;硫黄素T,碱性黄1;氯化2-;硫黄素 T;碱性黄 1
英文名称	Thioflavin T
英文别名	Thioflavine T;2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride;Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride;BASIC YELLOW 1;CI 49005;CI NO 49005;SETOFLAVINE T;2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo-[d]thiazol-3-ium chloride;2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride;THIOFLAVINE T C.I. NO. 49005 BIOLOGICAL STAIN;Acronol Yellow T;Setoflavin T;THIOFLAVIN T;Thioflavine TCN;THIOFLAVINE TG;THIOFLAVINET,TG;C.I. 49005;2-[4-(Dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride;C.I. Basic Yellow 1;Tannoflavine T;Rhoduline Yellow;Thioflavin TG;Thioflavin TCN;Primoflavine 8G;Citroflavine 8G;Purimofurabin 8G;Basic Yellow T;Thioflavine TCND;Acronol Yellow TC;Methylene Yellow N;Brilliant Flavine T;Methylene Yellow NI;Thioflavin TCN extra;Acronol Lake Yellow T;Acronol L;Basic Yellow 1;Setoflavine T;Thioflavin T
Cas No.	2390-54-7
分子式	C₁₇H₁₉ClN₂S
分子量	318.86
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	Thioflavin T 是一种阳离子 Benzothiazole 染料，在组织切片中与淀粉样蛋白结合后荧光强度增强。

产品详情	Thioflavin T 是一种阳离子 Benzothiazole 染料，在组织切片中与淀粉样蛋白结合后荧光强度增强。
生物活性	Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections.
性状	Solid
体外研究(In Vitro)	Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration show
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Khurana R, et al. Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol. 2005 Sep;151(3):229-38.

溶解度数据	In Vitro: DMSO : 16.67 mg/mL (52.28 mM; Need ultrasonic)H₂O : 12.5 mg/mL (39.20 mM; Need ultrasonic)配制储备液

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[1]. Khurana R, et al. Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol. 2005 Sep;151(3):229-38.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Thioflavin T

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