KRpep-2d TFA
目录号: PL10826 纯度: ≥98%
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中文名称
KRpep-2d TFA
英文名称
KRpep-2d TFA
包装储存
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
产品详情
KRpep-2d (TFA) 是一种有效的 K-Ras 抑制剂,抑制 K-Ras 驱动的癌细胞增殖。KRpep-2d (TFA) 可用于癌症研究。
生物活性
KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.
性状
Solid
IC50 & Target[1][2]
K-RAS
体外研究(In Vitro)
KRpep-2d (TFA) has cyclic structure with importance for K-Ras inhibitory activity. Leu7 , Ile , and Asp are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d.
KRpep-2d (TFA) (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
SequenceShortening
Ac-RRRRCPLYISYDPVCRRRR-NH2 (disulfide bridge: Cys5-Cys15)
参考文献
[1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.
溶解度数据
In Vitro: H2O : 100 mg/mL (37.38 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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