KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.
性状
Solid
IC50 & Target[1][2]
K-RAS
体外研究(In Vitro)
KRpep-2d (TFA) has cyclic structure with importance for K-Ras inhibitory activity. Leu7 , Ile , and Asp are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d. KRpep-2d (TFA) (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
[1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.
溶解度数据
In Vitro: H2O : 100 mg/mL (37.38 mM; Need ultrasonic)配制储备液