ML-098（CID-7345532）是GTP结合蛋白Rab7的激活剂，EC₅₀值为77.6nM。

ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC 50 of 77.6 nM.

Solid

EC50: 77.6 nM (Rab7)

Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively). has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Zurab Surviladze, et al. Three small molecule pan activator families of Ras-related GTPases. National Center for Biotechnology Information (US); 2010–.2009 May 18.

In Vitro: DMSO : ≥ 29 mg/mL (93.74 mM)配制储备液