ML141 (CID-2950007) 是一种高效、变构、选择性、可逆的 Cdc42 GTPase 非竞争性抑制剂。ML141 抑制 Cdc42 野生型和 Cdc42 Q61L 突变体的 EC₅₀ 值分别为 2.1 和 2.6 μM。ML141 对 GTPases Rho 家族的其他成员 (Rac1, Rab2, Rab7) 表现出低的微极性和选择性。ML141 在多个细胞系中没有显示细胞毒性。

ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC 50 s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines.

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ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively.
ML141 inhibits 3T3 fibroblast filopodia formation, and inhibits ovarian cancer cell migration. has not independently confirmed the accuracy of these methods. They are for reference only.

ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/6J mice

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Powder -20°C 3 years；4°C 2 years

[1]. Hong L, et al. Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem. 2013 Mar 22;288(12):8531-43.
[2]. Surviladze Z, et al. A Potent and Selective Inhibitor of Cdc42 GTPase. Probe Reports from the NIH Molecular Libraries Program
[3]. Hanin G, et al. Competing targets of mi

In Vitro: DMSO : ≥ 55 mg/mL (134.97 mM)配制储备液