TCH-165|1446350-60-2|-陌孚医药/Medlife

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TCH-165

目录号: PL10724 纯度: ≥99%

CAS No. :1446350-60-2

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中文名称	TCH-165
英文名称	TCH-165
英文别名	Ethyl (4S,5S)-3-benzyl-4-[4-(benzylamino)phenyl]-2-(4-methoxyphenyl)-5-phenyl-4H-imidazole-5-carboxy;TCH-165
Cas No.	1446350-60-2
分子式	C₃₉H₃₇N₃O₃
分子量	595.73
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	TCH-165 是蛋白酶体组装的小分子调节剂，可增加 20S 水平并促进 20S 介导的蛋白质降解。
生物活性	TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation.
性状	Solid
IC50 & Target[1][2]	Proteasome assembly
体外研究(In Vitro)	TCH-165 (0.01-10 μM; 72 hours; RPMI8226 and U87MG cells) treatment inhibits cell growth of RPMI8226 and U87MG cells with IC50 of 1.6 μM and 2.4 μM, respectively. TCH-165 (0-10 μM; 24 hours; HEK293T cells) treatment enhances ODC degradation is blocked by BTZ indicated that this event is proteasome-mediated. TCH-165 enhances proteolytic degradation in a concentration-dependent manner. TCH-165 enhances the chymotrypsin-like (CT-L), trypsin-like (Tryp-L) and caspase-like (Casp-L) activities with EC50s of 4.2 μM, 3.2 μM and 4.7 μM, respectively. TCH-165 enhances 20S-mediated degradation of IDPs, α-syn, and tau in vitro, and does not induce the degradation of structured proteins such as GAPDH. TCH-165-treated cells display a decrease in the assembled 26S and an increase in the 20S proteasome. TCH-165 regulates the dynamic equilibrium between the 20S and 26
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Njomen E, et al. Small Molecule Modulation of Proteasome Assembly. Biochemistry. 2018 Jul 17;57(28):4214-4224.

溶解度数据	In Vitro: DMSO : 250 mg/mL (419.65 mM; Need ultrasonic)配制储备液

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