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MG-115

目录号: PC16205 纯度: ≥98%

蛋白酶体抑制剂,MG115 is an inhibitor of NFκB in the cytoplasm by acting on IKK or the proteasome.

CAS No. :133407-86-0

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中文名称	MG-115
中文别名	MG115,蛋白酶体抑制剂
英文名称	MG-115
英文别名	L-Leucinamide,N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-;(S)-MG115;MG-115;MG-115 (Z-LL-Nva-CHO);Z-Leu-Leu-Norvalinal;benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate;MG115 Z-LLnV;MG115;Z-LLnV;Z-LL-NVA-CHO;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;Z-LEU-LEU-NVA-ALDEHYDE;N-CBZ-LEU-LEU-NORVALINAL
Cas No.	133407-86-0
分子式	C₂₅H₃₉N₃O₅
分子量	461.59
包装储存	-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
详情描述	蛋白酶体抑制剂,MG115 is an inhibitor of NFκB in the cytoplasm by acting on IKK or the proteasome.

生物活性

MG-115 is a potent and reversible proteasome inhibitor, with K_is of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.

性状

Solid

IC50 & Target[1][2]

Ki: 21 nM (20S proteasome); 35 nM (26 Sproteasome)

体外研究(In Vitro)

MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells.
MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK₁₈ DNA condensates.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HepG2 cells
Concentration:	0.1, 1, 2, 5, 10 μM
Incubation Time:	24 hours
Result:	Dose-dependently decreased cell viability. Inhibited the proteasomal activity, with an IC₅₀ of 2?μM.