Levocetirizine dihydrochloride|130018-87-0|((R)-Cetirizine dihydrochloride)-陌孚医药/Medlife

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Levocetirizine dihydrochloride (Synonyms: (R)-Cetirizine dihydrochloride)

目录号: PL06302 纯度: ≥99%

CAS No. :130018-87-0

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中文名称	Levocetirizine dihydrochloride
中文别名	盐酸左旋西替利嗪;[2-(4-(对氯苯基苄基)-1-哌嗪基)乙氧基]醋酸二盐酸盐;盐酸左旋西替利嗪盐酸盐;盐酸左西替利嗪;左西替利嗪二盐酸盐;(R)-Cetirizine丁二盐酸盐(左西替利丁二盐酸盐);Z-异亮氨酰-叔丁基谷氨酰-丙氨酸-亮氨酸缩醛;东革阿里;盐酸萘法唑酮;盐酸西替利嗪;盐酸左旋西替利嗪标准品;左西替利二盐酸盐 USP标准品;左西替利嗪;左旋西替利嗪;2-[2-[4-[(R)-(4-氯苯基)苯甲基]哌嗪-1-基]乙氧基]乙酸二盐酸盐;左旋盐酸西替利嗪;盐酸左硒替利嗪;左旋西替利嗪盐酸盐;盐酸左旋西替利嗪1;(R)-二盐酸西替利嗪;天然提取物盐酸左旋西替利嗪;盐酸左旋西替利嗪厂家
英文名称	Levocetirizine dihydrochloride
英文别名	Levocetirizine dihydrochloride;Levocetirizine;LEVOCETIRIZINE 2HCL;LEVOCETIRIZINE DIHCL;LEVOCETIRIZINE HCL;LEVOCETRIZINE DIHYDROCHLORIDE;[2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride;LevocetrizineHCl;LEVOCITIRIZINE DIHYDROCHLORIDE;Levo cetirzine dihydrochloride;2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid hydrochloride;Levocetirizine diHCl;(-)-Cetirizine dihydrochloride;2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic Acid Dihydrochloride;DDDB;Levocitirizine 2HCL;(R)-Form dihydrochloride;2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride;(R) -2-[2-[4-[(4-Chlorophenyl) Phenylmethyl] Piperazin-1-yl]Ethoxy]Acetic Acid Dihydrochloride;(R)-Cetirizine dihydrochloride;(-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride;[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride;LEVOCETIRIZINE DIHYDROCHLORIDE
Cas No.	130018-87-0
分子式	C₂₁H₂₅ClN₂O₃^.₂(HCl)
分子量	461.81
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) 是第三代 peripheral H1-receptor 拮抗剂。Levocetirizine dihydrochloride 是一种抗组胺剂，是 Cetirizine 的 R 对映体。Levocetirizine dihydrochloride 对组胺 H1-受体的亲和力高于 (S)-Cetirizine，并且可用于研究变应性鼻炎和慢性特发性荨麻疹。

生物活性

Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

性状

Solid

体内研究(In Vivo)

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the C max , AUC 0-t , AUC 0-∞ and t 1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672.

溶解度数据	In Vitro: DMSO : 100 mg/mL (216.54 mM; Need ultrasonic)H₂O : 100 mg/mL (216.54 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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