GnRH-I 是一种十肽，源于下丘脑，主要通过调节 GnRH 受体 (GnRHR) 介导的垂体部位有生物活性的促卵泡激素 (FSH)、促黄体激素 (LH) 的释放而发挥作用。

GnRH-I is a decapeptide of hypothalamic origin. GnRH-I acts primarily by regulating the release of biologically active follicle stimulating hormone (FSH) and luteinising hormone (LH) from the pituitary site mediated by the GnRH receptor (GnRHR).

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GnRH-I (0.001-10 μM, 72 h) leads to a significant increase in cell proliferation of PMBC cell lines. Moreover, cells co-treated with IL-2 (50 U/mL) and GnRH-I exhibits a higher proliferative response than IL-2 treatment alone.
GnRH-I (0.001-10 μM, 24 h) can effectively increase the expression of IL-2R mRNA of 162.3% compared to the control group in PMBCs.
GnRH-I (10 nM, 3 h) can be expressed in human T cells and activates T cell production of laminin receptors while induces chemotaxis of normal human T cells to a key chemokine, stromal cell-derived factor-1α, through a lamina-coated filter.
GnRH-I (10 nM, 72 h) significantly increases the migration of EL-4 t -lymphoma cells to the bone marrow and spleen of mice, but does not increase the migration of EL-4 to the thymus, kidney and liver, nor does it increase the number of EL-4 cells in plasma.

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

Pyr-HWSYGLRPG-NH2

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Others

[1]. F Tanriverdi, et al. GnRH-I and GnRH-II have differential modulatory effects on human peripheral blood mononuclear cell proliferation and interleukin-2 receptor gamma-chain mRNA expression in healthy males. Clin Exp Immunol. 2005 Oct;142(1):103-10.
[2]. Alon Chen, et al. The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. Nat Med. 2002 Dec;8(12):1421-6.

In Vitro: H₂O : 50 mg/mL (42.29 mM; Need ultrasonic)配制储备液