Lanreotide acetate|2378114-72-6|-陌孚医药/Medlife

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Lanreotide acetate

目录号: PL05925 纯度: ≥99%

CAS No. :2378114-72-6

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中文名称	Lanreotide acetate
英文名称	Lanreotide acetate
英文别名	BIM 23014 acetate;Lanreotide acetate;Somatuline Depot;Somatuline LP;Lanreotide (acetate);Ipstyl;Somatuline;Somatuline Autogel;Somatulina;Somatuline LA
Cas No.	2378114-72-6
分子式	C₅₆H₇₃N₁₁O₁₂S₂
分子量	1156.38
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情

Lanreotide (BIM 23014) acetate 是一种具有抗肿瘤活性的生长抑素类似物。Lanreotide acetate 可用于类癌综合症的研究。

生物活性

Lanreotide (BIM 23014) acetate is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for the research of carcinoid syndrome.

性状

Solid

体外研究(In Vitro)

Lanreotide (BIM 23014) (100? nM; 0-48 h) enhanced radiation-induced apoptosis.
Lanreotide results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide at concentrations of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 is 57?nM.
Lanreotide inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male nude mice, 8 weeks old and 20–25?g in

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

ClinicalTrial

SequenceShortening

{d-2nal}-CY-{d-Trp}-KVCT-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence

{d-2nal}-Cys-Tyr-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)

参考文献

[1]. Ning S, et al. Lanreotide promotes apoptosis and is not radioprotective in GH3 cells.Endocr Relat Cancer. 2009 Sep;16(3):1045-55.
[2]. Florio T, et al. Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.Clin Endocrinol (Oxf). 2003 J

溶解度数据	In Vitro: DMSO : 100 mg/mL (86.48 mM; Need ultrasonic)H₂O : 25 mg/mL (21.62 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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