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产品总数：60959
| 中文名称 |
Iopanoic acid
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|---|---|
| 中文别名 |
碘番酸;三碘氨苯乙基丙酸;Iopanoic Acid 碘番酸;碘番酸 标准品;碘泛酸;碘泛酸 EP标准品;2-(3-氨基--2,4,6-三碘苯基)丁酸;2-乙基-3-(3-氨基-2,4,6-三碘苯)丙酸
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| 英文名称 |
Iopanoic acid
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| 英文别名 |
2-(3-Amino-2,4,6-triiodobenzyl)butanoic acid;2-(3-amino-2,4,6-triiodobenzyl)butyric acid;Iodopanoicacid;Iopanoic Acid;2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid;Bilijodon;Choladine;Cholevid;Iopagnost;Jopanoic acid;Polognost;Telepaque;3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropanoic acid;3-Amino-α-ethyl-2,4,6-triiodohydrocinnamic Acid;3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropionic Acid;2-Ethyl-3-(3-amino-2,4,6-triiodophenyl)propionic acid;Iodopanoic acid;Iopanoicum;iopanic acid;Copanoic;Colepax;Cistobil;Jopagnost;Teletrast;Acidum iopanoicum;Iodopanic acid;Acide iopanoique [French];Acidum iopanoicum [INN-Latin];Acido iopanoico [INN-Spanish];Acide iopanoique [INN-French];Acido iopanoico [Latin,Spanish];2-[(3-amino-2,4,6-triiodophen;3-Amino-α-ethyl-2,4,6-triiodobenzenepropanoic acid (ACI);Hydrocinnamic acid, 3-amino-α-ethyl-2,4,6-triiodo- (6CI, 7CI, 8CI);(±)-Iopanoic acid;2-(3-Amino-2,4,6-triiodobenzyl)butyric acid;2-[(3-Amino-2,4,6-triiodophenyl)methyl]butanoic acid;2-[(5-Amino-2,4,6-triiodophenyl)methyl]butanoic acid;3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropionic acid;3-Amino-α-ethyl-2,4,6-triiodohydrocinnamic acid;Iopanoic acid;MeSH ID: D007480;NSC 41706;α-Ethyl-β-(3-amino-2,4,6-triiodophenyl)propionic acid
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| Cas No. |
96-83-3
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| 分子式 |
C11H12I3NO2
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| 分子量 |
570.93
|
| 包装储存 |
Powder -20°C 3 years；4°C 2 years
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| 产品详情 |
Iopanoic acid 是一个 5'-Deiodinase 抑制剂，也是一种碘造影剂。
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|---|---|
| 生物活性 |
Iopanoic acid is an inhibitor of 5-Deiodinase and also an iodinated contrast medium.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
5-Deiodinase
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| 体外研究(In Vitro) |
The thyrotropin-releasing-hormone (TRH)-induced thyrotropin (TSH) release from the pituitary fragments is inhibited by 3,5,3-triiodothyronin (T3) (10 M), by triiodothyroacetic acid (10 to 10 M), and by high concentrations of iodide (10 or 10 M). Iopanoic acid has no significant effect at the concentrations tested. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Iopanoic acid (IOP) administration to pregnant rats during days 18 and 19 postconception does not modify litter size (controls: 11.8±0.5 fetusesldam, Iopanoic acid-treated: 11.6±0.6 fetusesldam) or body weight at day 20 (controls: 3.27±0.12 g, Iopanoic acid-treated: 3.42±0.20 g). Iopanoic acid treatment produces a significant blockage of 5-Deiodinase (5D) activity in interscapular brown adipose tissue (IBAT) and brain; in contrast, liver 5D is not modified. 3,5,3-triiodothyronin (T 3 ) content is similar in IBAT and slightly increased in brain and liver nuclei of Iopanoic acid-treated fetuses when compare with control fetuses at day 20 (p<0.05). However, when administered to adult rats, Iopanoic acid produces a significant reduction in IBAT nuclear T 3 content and plasma T 3 concentration. Iopanoic acid inhibition of IBAT 5D activity in fetuses
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
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| 参考文献 |
[1]. Tuca A, et al. Inhibition of iodothyronine 5-deiodinase by iopanoic acid does not block nuclear T3 accumulation during rat fetal development. Pediatr Res. 1994 Jan;35(1):91-5.[2]. Szabolcs I, et al. Effects of triiodothyronine, triiodothyroacetic acid, iopanoic acid and iodide on the thyrotropin-releasing hormone-induced thyrotropin release from superfused rat pituitary fragments. Acta Endocrinol (Copenh). 1991 Oct;125(4):427-34.
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| 溶解度数据 |
In Vitro: DMSO : 100 mg/mL (175.15 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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