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Phenylephrine-2,4,6-d3 (hydrochloride)

目录号: PL05349

Phenylephrine-2,4,6-d3 (hydrochloride) 是 Phenylephrine hydrochloride 的氘代物。(R)-(-)-Phenylephrine hydrochloride是一种选择性的α1-肾上腺素能受体激动剂，对α1D，α1B 和α1A 受体的pKis 分为5.86，4.87和4.70。

CAS No. :1276197-50-2

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中文名称	Phenylephrine-2,4,6-d3 (hydrochloride)
中文别名	盐酸苯肾上腺素-D3氘代内标;(R)-(-)-去氧-D3盐酸;(R)-(-)-盐酸脱羟肾上腺素-D3;盐酸苯肾上腺素-D3;[2H3] -R-( - ) - 去氧肾上腺素HCL
英文名称	Phenylephrine-2,4,6-d3 (hydrochloride)
英文别名	(R)-(-)-Phenylephrine-2,4,6-d3?HCl;(R)-(-)-Phenylephrine-d3 HCl;Phenylephrine Impurity 47((R)-Phenylephrine-d3 HCl);(R)-(-)-Phenylephrine D3 HydrochlorideQ: What is (R)-(-)-Phenylephrine D3 Hydrochloride Q: What is the CAS Number of (R)-(-)-Phenylephrine D3 Hydrochloride Q: What is the storage condition of (R)-(-)-Phenylephrine D3 Hydrochloride Q: What are the applications of (R)-(-)-Phenylephrine D3 Hydrochloride
Cas No.	1276197-50-2
分子式	C₉H₁₄ClNO₂
分子量	206.68
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.
详情描述	Phenylephrine-2,4,6-d3 (hydrochloride) 是 Phenylephrine hydrochloride 的氘代物。(R)-(-)-Phenylephrine hydrochloride是一种选择性的α1-肾上腺素能受体激动剂，对α1D，α1B 和α1A 受体的pKis 分为5.86，4.87和4.70。

产品详情	Phenylephrine-2,4,6-d₃ (hydrochloride) 是 Phenylephrine hydrochloride 的氘代物。(R)-(-)-Phenylephrine hydrochloride是一种选择性的α₁-肾上腺素能受体激动剂，对α_1D，α_1B 和α_1A 受体的pK_is 分为5.86，4.87和4.70。
生物活性	Phenylephrine-2,4,6-d 3 (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.

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[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.

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Phenylephrine-2,4,6-d3 (hydrochloride)

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