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NG 52

(Synonyms: Compound 52)

目录号: PL04362 纯度: ≥99%

NG 52 是一种有效的，选择性的 ATP 兼容且具有口服活性的 Cdc28p 和 Pho85p 激酶抑制剂，IC50 分别为 7 μM 和 2 μM。NG 52 还以 IC50 值为 2.5 μM 来抑制磷酸甘油酸激酶 1 (PGK1) 的活性。NG 52 对酵母激酶 Kin28p，Srb10 和 Cak1p 无活性。

CAS No. :212779-48-1

商品编号	规格	价格	会员价
PL04362-5mg	5mg	¥1175.00	请登录
PL04362-10mg	10mg	¥2155.00	请登录
PL04362-50mg	50mg	¥5285.00	请登录
PL04362-100mg	100mg	¥7485.00	请登录
PL04362-200mg	200mg	询价	询价
PL04362-500mg	500mg	¥14895.00	请登录
PL04362-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2565.00	请登录
PL04362-1 mL x 10 mM (in DMSO)		¥1285.00	请登录

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中文名称	NG 52
中文别名	2-((6-((3-氯苯基)氨基)-9-异丙基-9H-嘌呤-2-基)氨基)乙醇;2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇
英文名称	NG 52
英文别名	2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol;compound 52;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;NG-52;NG 52;OLP;3bpr;AC1L1EMK;SureCN1181087
Cas No.	212779-48-1
分子式	C₁₆H₁₉N₆OCl
分子量	346.81
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	NG 52 是一种有效的，选择性的 ATP 兼容且具有口服活性的 Cdc28p 和 Pho85p 激酶抑制剂，IC50 分别为 7 μM 和 2 μM。NG 52 还以 IC50 值为 2.5 μM 来抑制磷酸甘油酸激酶 1 (PGK1) 的活性。NG 52 对酵母激酶 Kin28p，Srb10 和 Cak1p 无活性。

产品详情	NG 52 是一种有效的，选择性的 ATP 兼容且具有口服活性的 Cdc28p 和 Pho85p 激酶抑制剂，IC₅₀ 分别为 7 μM 和 2 μM。NG 52 还以 IC₅₀ 值为 2.5 μM 来抑制磷酸甘油酸激酶 1 (PGK1) 的活性。NG 52 对酵母激酶 Kin28p，Srb10 和 Cak1p 无活性。
生物活性	NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC 50 s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC 50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p.
性状	Solid
IC50 & Target[1][2]	cdc2-cyclin B 0.34 μM (IC50) Pho85p 2 nM (
体外研究(In Vitro)	NG 52 (Compound 52) inhibits growth in a drug-sensitized yeast strain ( S. cerevisiae ) with a GI50 of 30 μM. NG 52 is active against cdc2-cyclin B with an IC50 value of 340 nM. NG 52 dose-dependently inhibits the proliferation of glioma U87 and U251 cell lines with GI50 values of 7.8 μM and 5.2 μM, respectively, meanwhile it potently inhibits the proliferation of primary glioma cells. NG 52 (12.5-50 μM) effectively inhibits the phosphorylation of PDHK1 at Thr338 site and the phosphorylation of PDH at Ser293 site in U87 and U251 cells, resulting in more pyruvic acid entering the Krebs cycle with increased production of ATP and ROS. NG 52 can reverse the Warburg effect by enhancing the activity of pyruvate dehydrogenase (PDH) through inhibiting the activity of PGK1, and switched cellular glucose metabolism from anaerobic mode
体内研究(In Vivo)	NG 52 (50-150 mg/kg; oral administration; daily; for 13 days) treatment dose-dependently suppresses the growth of glioma xenograft. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Fem
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. [2]. Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31.

溶解度数据	In Vitro: DMSO : 75 mg/mL (216.26 mM; Need ultrasonic)配制储备液

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[1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8.
[2]. Wen-Liang Wang, et al. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin. 2020 Jul 31.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

NG 52

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