M2N12
目录号: PL02972 纯度: ≥98%
CAS No. :2376577-06-7
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中文名称
M2N12
英文名称
M2N12
英文别名
M2N12;BDBM50504275;6-Chloro-7-[[1-[(4-methylphenyl)methyl]triazol-4-yl]methylamino]quinoline-5,8-dione
Cas No.
2376577-06-7
分子式
C20H16ClN5O2
分子量
393.83
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
M2N12 是一种有效且高度选择性的细胞分裂周期蛋白磷酸酶 25C (Cdc25C) 抑制剂,IC50 值为 0.09 μM。 M2N12 还具有抑制 Cdc25A 和 Cdc25B 的活性,IC50 值分别为 0.53 μM 和 1.39 μM。M2N12 具有抗肿瘤活性,可用于癌症研究。
生物活性
M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC 50 value of 0.09 ?μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC 50 values of ?0.53? μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research.
性状
Solid
体外研究(In Vitro)
M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively).
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Jing L, et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem. 2019 Sep 14;183:111696.
溶解度数据
In Vitro: DMSO : 11.11 mg/mL (28.21 mM; ultrasonic and warming and heat to 67°C)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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