Subasumstat|1858276-04-6|(TAK-981)-陌孚医药/Medlife

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Subasumstat (Synonyms: TAK-981)

目录号: PL01962 纯度: ≥99%

CAS No. :1858276-04-6

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中文名称	Subasumstat
英文名称	Subasumstat
英文别名	XQ43H3V6M1;LXRZVMYMQHNYJB-UNXOBOICSA-N;TAK 981; TAK981;BCP30806;[(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-thiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxy-cyclopentyl]methyl sulfamate;((1R,2S,4R)-4-((5-((4-((1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl)carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate;[(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl;Subasumstat
Cas No.	1858276-04-6
分子式	C₂₅H₂₈ClN₅O₅S₂
分子量	578.10
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Subasumstat (TAK-981) 是首创的、SUMOylation 酶联反应的选择性抑制剂，具有潜在的免疫激活和抗肿瘤活性。

生物活性

Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.

性状

Solid

IC50 & Target[1][2]

SUMOylation.

体外研究(In Vitro)

Subasumstat (TAK-981) is able to increase the production of type 1 IFN, thereby increasing type 1 IFN-mediated signaling, activating innate effector cells and enhancing the antitumor innate immune responses. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

A single sub-cutaneous injection of Subasumstat (TAK-981) in naive Balb/c mice at the brachial lymph nodes induces activation of DCs. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Sumoylation inhibitor TAK-981.
[2]. TAK-981.