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DKM 2-93

目录号: PL01295 纯度: ≥98%

DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。

CAS No. :65836-72-8

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中文名称	DKM 2-93
中文别名	2-[(苯磺酰)甲基]苄基溴;2-氯-n-(3,4-二甲氧基苄基)乙酰胺;乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-
英文名称	DKM 2-93
英文别名	2-Chloro-N-(3,4-dimethoxybenzyl)acetamide;2-chloro-N-[(3,4-dimethoxyphenyl)methyl]acetamide;2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;Acetamide,2-chloro-N-((3,4-dimethoxyphenyl)methyl);C-Chlor-N-veratryl-acetamid;Chlor-essigsaeure-veratrylamid;chloro-acetic acid veratrylamide;N-(3.4-Dimethoxy-benzyl)-chloracetamid;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [French];N-Chloracetyl-(3,4-dimethoxyphenyl)methylamin;N-chloroacetyl-3,4-dimethoxybenzylamine;DKM 2-93;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;2-Chloro-N-(3,4-dimethoxy-benzyl)-acetamide;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;BCP32598;7547AE;BBL017809;s5841;STK482932
Cas No.	65836-72-8
分子式	C₁₁H₁₄ClNO₃
分子量	243.69
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。

产品详情	DKM 2-93是相对选择性的UBA5抑制剂，IC₅₀值为430 μM。
生物活性	DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC 50 of 430 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
体外研究(In Vitro)	Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Roberts AM, et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target. ACS Chem Biol. 2017 Apr 21;12(4):899-904.

溶解度数据	In Vitro: DMSO : 125 mg/mL (512.95 mM; Need ultrasonic)配制储备液

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[1]. Roberts AM, et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target. ACS Chem Biol. 2017 Apr 21;12(4):899-904.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

DKM 2-93

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