476-66-4|Ellagic acid，≥98%|Medlife|Medlife为MCE，Selleck，麦克林，阿拉丁试剂，罗恩试剂，Sigma，安耐吉试剂，泰坦等同类产品品牌，上海现货，高性价比小分子化合物

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Ellagic acid.

Ellagic acid 是一种天然的抗氧化剂，为有效的，ATP 竞争性的 CK2 抑制剂，IC50 和 Ki 值分别为 40 nM 和 20 nM。

目录号: PC10259 纯度: ≥98%

CAS No. :476-66-4

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中文名称

Ellagic acid.

中文别名

鞣花酸;2,3,7,8-四羟基-[1]-苯并吡喃并[5,4,3-CDE][1]苯并吡喃-5,10-二酮;倍原;二缩双(三羟基甲酸);花酸;棓原;逆没食子酸;柔花酸;二缩双(三羟基苯甲酸);.石榴皮提取物;鞣花酸标准品;鞣花酸(P);鞣花酸(石榴)Ellagic acid;鞣花酸,Ellagic acid,植物提取物,标准品,对照品;鞣花酸Ellagic acid;石榴皮提取物;石榴皮提取物鞣花酸安石榴甙多酚;石榴提取物;棓原,逆没食子酸,二缩双(三羟基甲酸), 2,3,7,8-四羟基-[1]-苯并吡喃并[5,4,3-CDE][1]苯并吡喃-5,10-二酮;没食子酸;鞣花酸,Ellagic acid,鞣花酸;鞣花酸,二缩双(三羟基苯甲酸)

英文名称

Ellagic acid

英文别名

Ellagic acid hydrate;ellagic acid from chestnut bark;Ellagic acid dihydrate;4,4,5,5-tetrahydroxybiphenyl-2,6:2,6-biscarbolactone;Ellagic acid;Pomegranate Extract;2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione;4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID 2,6,2',6'-DILACTONE;ELLAGIC ACID(P) PrintBack;ELLAGIC ACID(RG);Elllagic Acid;2, 3, 7, 8-Tetrahydroxy-[1]-benzopyrano-[5, 4, 3, cde]-[1]-benzopyran-5, 10-dione;4, 4′, 5, 5′, 6, 6′-Hexahydroxydiphenic acid 2, 6, 2′, 6′-;BENZOARIC ACID;elagostasine;eleagicacid;Ellagic;Gallogen;lagistase;4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone;2,3,7,8-tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione;[ "" ];Eleagic acid;Alizarine Yellow;Llagic acid;Acide ellagique;Acido elagico;Acidum ellagicum;C.I. 55005;Gallogen (VAN);Gallogen (astringent);C.I. 75270;Ellagate;Ellagic acid [INN:DCF];Acido elagico [INN-Spanish];Gallogen, astringent;Acide ellagique [INN-French];Acidum ellagicum [INN-Latin];MLS000069632;C14H6O8

Cas No.

476-66-4

分子式

C₁₄H₆O₈

分子量

302.19

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM.

性状

Solid

IC50 & Target[1][2]

CK2

40 nM (IC₅₀)

体外研究(In Vitro)

Ellagic acid is a potent CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM. Ellagic acid also blocks other kinases such as LYN, PKA, SYK, GSK3, FGR and CK1, with IC₅₀s of 2.9, 3.5, 4.3, 7.5, 9.4 and 13.0 μM, respectively, and shows no obvious effects on DYRK1a, CSK, NPM-ALK, RET and FLT3 (IC₅₀s > 40 μM). Ellagic acid (5-100 μM) shows inhibitory activities against Karpas299, SUDHL1, SR786, and FE-PD cell lines. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

结构分类

来源

参考文献

[1]. Cozza G, et al. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6. [Information]

[2]. Rizk HA, et al. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017 Dec;31(12). [Information]

[3]. Ahire V, et al. Ellagic Acid Enhances Apoptotic Sensitivity of Breast Cancer Cells to γ-Radiation. Nutr Cancer. 2017 Aug-Sep;69(6):904-910. [Information]

溶解度数据

体外研究:

DMSO : ≥ 2.5 mg/mL (8.27 mM)

Ethanol : < 1 mg/mL (insoluble)

H₂O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3092 mL	16.5459 mL	33.0918 mL
5 mM	0.6618 mL	3.3092 mL	6.6184 mL
10 mM	---	---	---

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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