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DSPE-MPEG(2000) (sodium salt)

目录号: PC22067 纯度: ≥90%

DSPE-MPEG(2000) is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE .

CAS No. :459428-35-4

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中文名称	DSPE-MPEG(2000) (sodium salt)
英文名称	DSPE-MPEG(2000) (sodium salt)
英文别名	1,2-Distearoyl-rac-glycero-3-PE-N-Polyethyleneglycol-2000 1,2-Distearoyl-rac-glycerol-3-Phosphatidylethanolamine-N-Polyethyleneglycol-2000 1,2-Distearoyl-rac-glycerol-3-Phosphoethanolamine-N-Polyethyleneglycol-2000 1,2-DSPE-MPEG(2000)
Cas No.	459428-35-4
分子式	(C₂H₄O)NC₄₃H₈₃NO₁₀P^.Na
分子量	872.14
包装储存	-20°C
详情描述	DSPE-MPEG(2000) is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used in the synthesis of liposomes for the delivery of anticancer and antimalarial agents.1,2,3

生物活性	DSPE-MPEG(2000) is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095). Formulations containing DSPE-MPEG(2000) have been used in the synthesis of liposomes for the delivery of anticancer and antimalarial agents.1,2,3
性状	A solid
运输条件	冷藏运输。
储存方式	-20°C
参考文献	1. Hasan, G.M., Garg, N., Dogra, E., et al. Inhibition of the growth of Plasmodium falciparum in culture by stearylamine-phosphatidylcholine liposomes. J. Parasitol. Res. 120462 (2011). 2. Rathore, S.S., and Ghosh, P.C. Effect of surface charge and density of distearylphosphatidylethanolamine-mPEG-2000 (DSPE-mPEG-2000) on the cytotoxicity of liposome-entrapped ricin: Effect of lysosomotropic agents. Int. J. Pharm. 350(1-2), 79-94 (2008). 3. Haghiralsadat, F., Amoabediny, G., Helder, M.N., et al. A comprehensive mathematical model of drug release kinetics from nano-liposomes, derived from optimization studies of cationic PEGylated liposomal doxorubicin formulations for drug-gene delivery. Artif. Cells Nanomed. Biotechnol. 46(1), 169-177 (2018).

溶解度数据	Chloroform: 10 mg/ml DMF: 2.5 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml

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1. Hasan, G.M., Garg, N., Dogra, E., et al. Inhibition of the growth of Plasmodium falciparum in culture by stearylamine-phosphatidylcholine liposomes. J. Parasitol. Res. 120462 (2011).
2. Rathore, S.S., and Ghosh, P.C. Effect of surface charge and density of distearylphosphatidylethanolamine-mPEG-2000 (DSPE-mPEG-2000) on the cytotoxicity of liposome-entrapped ricin: Effect of lysosomotropic agents. Int. J. Pharm. 350(1-2), 79-94 (2008).
3. Haghiralsadat, F., Amoabediny, G., Helder, M.N., et al. A comprehensive mathematical model of drug release kinetics from nano-liposomes, derived from optimization studies of cationic PEGylated liposomal doxorubicin formulations for drug-gene delivery. Artif. Cells Nanomed. Biotechnol. 46(1), 169-177 (2018).

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

DSPE-MPEG(2000) (sodium salt)

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