Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC₅₀ of 15 μM (3.92 μg/mL).

Solid

Flumequine (R-802) is a topoisomerase II inhibitor, with an IC₅₀ of 3.92 μg/mL, and less potently inhibits Gyrase, with an IC₅₀ of 1764 μg/mL. Flumequine (0-625 μg/mL) increases migration of nuclear DNA from CHL cells. Flumequine (R-802) inhibits Spanish field isolates of B. hyodysenteriae with MIC₅₀ and MIC₉₀ of 50 and 100 μg/mL, and MBC₅₀ and MBC₉₀ of 50, 200 μg/mL, respectively. Flumequine (R-802) suppresses A. salmonicida isolates with MIC ranging from 0.06 to 32 μg/mL.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Flumequine (R-802) (0-500 mg/kg, p.o.) causes dose-related DNA damage in the stomach, colon, and urinary bladder of mice, 1 and 3 h but not 24 h after its administration.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transportation.

• [1]. Kashida Y, et al. Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice. Toxicol Sci. 2002 Oct;69(2):317-21.  [Information]

  [2]. Aller-Morán LM, et al. Evaluation of the 体外研究 activity of flumequine against field isolates of Brachyspira hyodysenteriae. Res Vet Sci. 2015 Dec;103:51-3.  [Information]

  [3]. Giraud E, et al. Mechanisms of quinolone resistance and clonal relationship among Aeromonas salmonicida strains isolated from reared fish with furunculosis. J Med Microbiol. 2004 Sep;53(Pt 9):895-901.  [Information]

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。