NU9056|1450644-28-6|-陌孚医药/Medlife

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NU9056

目录号: PL15146 纯度: ≥98%

CAS No. :1450644-28-6

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中文名称	NU9056
中文别名	5,5,′-二硫代双[异噻唑
英文名称	NU9056
英文别名	NU 9056;TNU9056 1,2-Di(isothiazol-5-yl)disulfane;5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole;1,2-Di(isothiazol-5-yl)disulfane;BCP17389;1,2-bis(isothiazol-5-yl)disulfane;BDBM50151660;CID 72201043;NU9056;TNU9056;5-(1,2-thiazol-5-yldisulfanyl)-1,2-thiazole;Isothiazole, 5,5'-dithiobis-;NU9056 1,2-Bis(isothiazol-5-yl)disulfane
Cas No.	1450644-28-6
分子式	C₆H₄N₂S₄
分子量	232.37
包装储存	Pure form -20°C 3 years；4°C 2 years

产品详情	NU9056 是一种有效的选择性 Tip60 (KAT5) 组蛋白乙酰转移酶抑制剂，为 2 µM。NU9056 对 Tip60 的选择性比 PCAF，p300 和 GCN5 高 16 倍以上。NU9056 诱导前列腺癌细胞凋亡 (apoptosis)。
生物活性	NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 μM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells.
性状	Solid-liquid mixture
体外研究(In Vitro)	NU9056 (17-36 μM; 24-96 hours) results in both caspase 3 and caspase 9 activation in a time- and concentration-dependent manner. NU9056 (2.5-40 μM; 2 hours) treatment results in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation. NU9056 treatment also decreases androgen receptor, prostate specific antigen, p53 and p21 protein levels. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The mice are injected with Nu9056 (2 μg/g) and the hippocampus is collected 1 h later. Tip60 inhibition reduces H2A.Z binding at the -1 nucleosome of Arc, and the +1 nucleosome of Arc and Syp. Additionally, Nu9056 increases acetylation at the -1 nucleosome of Fos, Tacstd2, and Gria4, and the +1 nucleosome of Gria4. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Kelly Coffey, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One. 2012;7(10):e45539. [2]. Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018.

溶解度数据	In Vitro: DMSO : 125 mg/mL (537.94 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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