Remodelin|949912-58-7|-陌孚医药/Medlife

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Remodelin

目录号: PL15129 纯度: ≥98.0%

CAS No. :949912-58-7

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中文名称	Remodelin
中文别名	Remodelin
英文名称	Remodelin
英文别名	Remodelin;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile (ACI)
Cas No.	949912-58-7
分子式	C₁₅H₁₄N₄S
分子量	282.36
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	Remodelin是乙酰基转移酶NAT10的新型强效选择性抑制剂。
生物活性	Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. IC50 value: Target: NAT10 inhibitor Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and s
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32.

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