Remodelin hydrobromide|1622921-15-6|-陌孚医药/Medlife

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Remodelin hydrobromide

目录号: PL15142 纯度: ≥99%

CAS No. :1622921-15-6

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中文名称	Remodelin hydrobromide
中文别名	Benzonitrile, 4-?[2-?(2-?cyclopentylidenehydr?azinyl)?-?4-?thiazolyl]?-?, hydrobromide (1:1);Remodelin (hydrobromide)
英文名称	Remodelin hydrobromide
英文别名	Benzonitrile, 4-?[2-?(2-?cyclopentylidenehydr?azinyl)?-?4-?thiazolyl]?-?, hydrobromide (1:1);Remodelin (hydrobromide);Remodelin hydrobromide;Remodelin HBR;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile Hydrobromide;C15H15BrN4S;C15H14N4S.BrH;AOB1653;SYN5222;AMY10829;BCP19055;XPC92115;4002AH;s7641;Remodelin hydrobromide, >=98% (HPLC);A14215;A900316;4-(2-(2-Cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile hydrobromide;4-[2-(2-cyclopentylidenehydrazin-1-yl)-1,
Cas No.	1622921-15-6
分子式	C₁₅H₁₅BrN₄S
分子量	363.28
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Remodelin 是特异性的 N-乙酰基转移酶 NAT10 的特异性抑制剂，能改善 Hutchinson-Gilford 早衰综合征细胞表型。Remodelin 通过靶向和抑制 NAT10，在一个不依赖于 progerin 和 FTI 的途径中发挥作用。NAT10 是一种具有组蛋白乙酰化活性的蛋白质，主要参与端粒酶活性的调节。
生物活性	Remodelin, a specific inhibitor of N-acetyltransferase NAT10, can ameliorate Hutchinson-Gilford Progeria Syndrom (HGPS) cellular phenotypes. Remodelin acts in a progerin- and FTI-independent pathway, by targeting and inhibiting NAT10. NAT10 is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity.
性状	Solid
体外研究(In Vitro)	Remodelin blocks invasion and migration of HCC cells in hypoxic conditions has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Remodelin (100?mg/kg; p.o) significantly reduces the loss of subcutaneous adipose tissue that is seen in the HGPS mouse model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Lmna mic
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Balmus G, et al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018;9(1):1700. Published 2018 Apr 27. [2]. Liu H, et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. Mol Cell Biochem. 2007;300(1-2):249-258.

溶解度数据	In Vitro: DMSO : ≥ 44 mg/mL (121.12 mM)H₂O : < 0.1 mg/mL (insoluble)

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