Ribocil-C是高度选择性的细菌核黄素核糖开关 (bacterial riboflavin riboswitches) 抑制剂。

Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

Solid

Bacterial riboflavin riboswitches

Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli . Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli , Pseudomonas aeruginosa , and Acinetobacter baumannii , to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth. has not independently confirmed the accuracy of these methods. They are for reference only.

Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log 10 [CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Wang H, et al. Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch DisruptRiboflavin Homeostasis in an Infectious Setting. Cell Chem Biol. 2017 May 18;24(5):576-588.
[2]. Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.

In Vitro: DMSO : 110 mg/mL (262.22 mM; Need ultrasonic)配制储备液