Fosfomycin calcium|26016-98-8|-陌孚医药/Medlife

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Fosfomycin calcium

目录号: PL14679 纯度: ≥98.0%

CAS No. :26016-98-8

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中文名称	Fosfomycin calcium
中文别名	磷霉素钙;[(2R,3S)-3-甲基环氧基]磷酸钙盐;磷霉素钙(水溶);Fosfomycincalcium,certified 标准品;磷霉素 (R)-1-苯乙胺盐;磷霉素钙 EP标准品;磷霉素钙标准品;水溶性磷霉素钙;优质高纯度磷霉素钙
英文名称	Fosfomycin calcium
英文别名	phosphomycin calcium;1,2-epoxypropyl)-,calciumsalt(1:1),(1r,2s)-(-)-phosphonicaci;(3-methyloxiranyl)-,calciumsalt(1:1),(2r-cis)-phosphonicaci;calciumfosfomycin;calciumphosphomycin;calciumphosphonomycin;fosmicin;Fosfomycin calcium;Fosfomycin calcium monohydrate;Phosphomycin calcium salt;Clulolaxin;Fosfomycin caclium(+/-);Fosfomycin calcium salt;Harosmin-S;PHOSPHOMYCIN;phosphonomycin calcium salt;(-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid;Fosfomycin (calcium);Calcium hydrogen (2R-cis)-(3-methyloxiranyl)phosphonate;76EIK6888N;Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (1:1);Phosphonic acid, (1,2-epoxypropyl)-, calcium salt (1:1), (1R,2S)-(-)-;Fosfomycin calcium [JAN];fosfomycin-calcium;Fosfocin (TN);AK163186
Cas No.	26016-98-8
分子式	C₃H₅CaO₄P
分子量	176.12
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Fosfomycin (MK-0955) calcium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。Fosfomycin calcium 对多种细菌具有杀菌活性，这些细菌包括耐多药 (MDR)，广泛耐药 (XDR) 和耐全药 (PDR) 细菌。

生物活性

Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

性状

Solid

体外研究(In Vitro)

Fosfomycin calcium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis.
Fosfomycin calcium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%.
Fosfomycin calcium displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Fosfomycin calcium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes.
Pharmacokinetic of Fosfomycin calcium in Rats
Dibekacin Dose (mg) V dss (l/kg) β (min

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Falagas ME, et al. Fosfomycin. Clin Microbiol Rev. 2016 Apr. 29(2):321-47.
[2]. Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31;6(4). pii: E24.
[3]. Inouye S, et al. Protective effect of fosfomycin on the experimental nephrotoxicity induced by

溶解度数据	In Vitro: H₂O : 50 mg/mL (283.90 mM; ultrasonic and adjust pH to 2 with HCl)DMSO : < 1 mg/mL (insoluble or slightly soluble)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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