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Polyoxyethylene stearate

目录号: PL14665

Polyoxyethylene stearate (POES) 是非离子乳化剂。

CAS No. :9004-99-3

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中文名称	Polyoxyethylene stearate
中文别名	聚乙二醇硬脂酸酯;聚氧乙烯山梨糖醇酐单硬脂酸酯;聚乙二醇(400)单十八酸酯;聚乙二醇(400)单硬脂酸酯;旅化T-60;聚氧乙烯硬脂酸酯;聚氧乙烯山梨糖醇酐单硬酸酯;PEG-5 硬脂酸酯;PEG-7 硬脂酸酯;聚乙二醇单硬脂酸酯;聚乙二醇单硬脂酸酯 n≈25(棕榈酸酯和硬脂酸酯的混合物);聚乙二醇单硬脂酸酯 n≈45 (棕榈酸酯和硬脂酸酯的混和物);聚乙二醇单硬脂酸酯 n≈40(棕榈酸酯和硬脂酸酯的混合物);聚乙二醇单硬脂酸酯 n≈55(棕榈酸酯和硬脂酸酯的混合物);聚乙二醇单硬脂酸酯 n≈10 (棕榈酸酯和硬脂酸酯的混合物);聚乙二醇单硬脂酸酯 n≈4 (棕榈酸酯和硬脂酸酯的混和物);聚乙二醇单硬脂酸酯 n≈2 (棕榈酸酯和硬脂酸酯的混和物);638增稠剂;PEG-10 硬脂酸酯;PEG-32 硬脂酸酯;PEG-40 硬脂酸酯;PEG-45 硬脂酸酯;PEG-50 硬脂酸酯;PEG-6 硬脂酸酯;PEG-75 硬脂酸酯;PEG-8 硬脂酸酯;PEG-9 硬脂酸酯;PEG-90 硬脂酸酯;聚氧乙烯(8)硬脂酸酯;聚乙二醇 400 单硬脂酸酯 PEG400MS;聚乙二醇10单硬脂酸酯;聚乙二醇400单硬脂酸酯 PEG400MS 乳化剂SG-9;聚乙二醇硬脂酸酯柔软剂SG-6;聚乙二醇硬脂酸酯乳化剂SG;聚乙二醇硬脂酸酯乳化剂SG-10 聚氧乙烯硬脂酸酯;聚乙二醇硬脂酸酯乳化剂SG-12 聚氧乙烯硬脂酸酯;聚乙二醇硬脂酸酯乳化剂SG-9 聚氧乙烯硬脂酸酯;聚乙二醇硬脂酸酯(10E.O.);聚乙二醇硬脂酸酯（n≈40）;聚乙二醇硬脂酸酯100;聚乙二醇硬脂酸酯32;聚乙二醇硬脂酸酯40;聚乙二醇硬脂酸酯50;聚乙二醇硬脂酸酯75;聚乙二醇硬脂酸酯8;硬脂酸聚烃氧（40）酯;硬脂酸聚乙二醇40 USP标准品;硬脂酸聚乙二醇50 USP标准品;硬脂酸聚乙二醇6;硬脂酸酯 PEG-100;聚氧乙烯硬脂酸酯(n-25)[284+44n];聚乙二醇（1000）单硬脂酸酯;聚乙二醇硬脂酸酯, 硬脂酸聚乙二醇酯,硬脂酸聚氧乙烯酯;聚乙二醇硬脂酸酯,乳化剂SG系列;硬脂酸聚氧乙烯酯;硬脂酸聚乙二醇酯;上皮钠通道蛋白 A 抗体
英文名称	Polyoxyethylene stearate
英文别名	polyoxyethylene 8 stearate;Polyethylene glycol monostearate;MYRJ(TM) 53;MYRJ(TM) 59;MYRJ 58;MYRJ 59;MYRJ(R) 53;MYRJ(TM) 45;MYRJ 45;PEG 200 STEARATE;Polyoxyethylene stearate;PEG1000monostearate;PEG1540monostearate;PEG300monostearate;PEG4000monostearate;PEG400monostearate;PEG600monostearate;POES;Poly(oxy-1,2-ethanediyl), .α.-hydro-.ω.-hydroxy-, octadecanoate;Polyethylene Glycol Monostearate (10E.O.);Polyethylene Glycol Monostearate (25E.O.);Polyethylene Glycol Monostearate (55E.O.);POLYETHYLENE GLYCOL MONOSTEARATE N-4 (PALMITATE AND STEARATE MIXTURE);Polyethylene Glycol Monostearate(45E.O.);n≈10;n≈100;n≈25;PEG-100 stearate;PEG-32 stearate;PEG-6 stearate;PEG-8 stearate;PEG-75 stearate;Myrj 52;PEG monostearate;ENaC alpha Antibody;2-Hydroxyethyl stearate;Glycol stearate;2-Hydroxyethyl octadecanoate;Ethylene glycol monostearate;Cremophor A;Cerasynt M;Clearate G;Cerasynt MN;Cithrol PS;Polyoxyl 40 stearate;Polystate;Lactine;Myrj;Cithrol 10MS;Cerasynt 660;Polystate B;Prodhybase P;Akyporox S 100;PEG stearate;Soromin-SG;Lamacit CA;Emerest 2640;Stearoks 6;Stearoxa-6;Stearox 6;Nikkol MYS;Pegosperse S 9;Glycol monostearate;Emanon 3113;Stenol 8;Emcol H 35-A;Arosurf 1855E40
Cas No.	9004-99-3
分子式	C₂₀H₄₀O₃
分子量	328.53
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Polyoxyethylene stearate (POES) 是非离子乳化剂。

产品详情	Polyoxyethylene stearate (POES) 是非离子乳化剂。
生物活性	Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.
性状	Solid
体外研究(In Vitro)	Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and as such has been shown to enhance growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis . Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when the cells are cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate.
体内研究(In Vivo)	Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms. The average tumor volume and average tumor weight are significantly less in the polyoxyethylene 40 stearate+vinblastine group. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20. [2]. Zhu S, et al. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80.

溶解度数据	In Vitro: DMSO : 100 mg/mL (Need ultrasonic)In Vivo:请根据您的实验动物和给药

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[1]. Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20.
[2]. Zhu S, et al. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Polyoxyethylene stearate

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