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Voxvoganan

目录号: PL14648

Voxvoganan (LTX-109) 是一种局部抗菌剂 (antimicrobial)，对 S. aureus 非常有效，MIC为2-4 μg/mL。Voxvoganan 可用于细菌性皮肤感染、真菌感染的研究。

CAS No. :1166254-80-3

商品编号	规格	价格	会员价	是否有货	数量
PL14648-5mg	5mg	询价	询价
PL14648-10mg	10mg	询价	询价

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中文名称	Voxvoganan
英文名称	Voxvoganan
英文别名	(2S)-2-amino-5-(diaminomethylideneamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(2-phenylethylamino)pentan-2-yl]amino]-1-oxo-3-(2,5,7-tritert-butyl-1H-indol-3-yl)propan-2-yl]pe;(2S)-2-amino-5-(diaminomethylideneamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(2-phenylethylamino)pentan-2-yl]amino]-1-oxo-3-(2,5,7-tritert-butyl-1H-indol-3-yl)propan-2-yl]pentanamide;Lytixar(LTX-109);LTX-109;L-Argininamide, L-arginyl-2,5,7-tris(1,1-dimethylethyl)-L-tryptophyl-N-(2-phenylethyl)-;Lytixar;Voxvoganan
Cas No.	1166254-80-3
分子式	C₄₃H₆₉N₁₁O₃
分子量	788.08
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.
详情描述	Voxvoganan (LTX-109) 是一种局部抗菌剂 (antimicrobial)，对 S. aureus 非常有效，MIC为2-4 μg/mL。Voxvoganan 可用于细菌性皮肤感染、真菌感染的研究。

产品详情

Voxvoganan (LTX-109) 是一种局部抗菌剂 (antimicrobial)，对 S. aureus 非常有效，MIC为2-4 μg/mL。Voxvoganan 可用于细菌性皮肤感染、真菌感染的研究。

生物活性

Voxvoganan (LTX-109), a topical antimicrobial, is highly effective against S. aureus with a MIC range of 2 to 4 μg/mL. Voxvoganan can be used for the research of bacterial skin infections, fungal infections and nasal decolonisation of MRSA.

体外研究(In Vitro)

Voxvoganan (LTX-109) is an investigational antimicrobial agent with a membrane-lysing mechanism of action, based on the biological principle of innate immune effectors, lytic peptides. Voxvoganan has a rapid bactericidal lytic activity. Voxvoganan demonstrates in vitro bactericidal activity against a number of S. aureus isolates resistant to several classes of antimicrobial agents evaluated in this study.
Voxvoganan (LTX-109) is a broad-spectrum, fast-acting bactericidal antimicrobial agent that binds to negatively charged membrane components on the bacterial cell wall, which leads to membrane disruption and cell lysis. Voxvoganan is a first-in-class chemically synthesized, small peptide drug that is stable against protease degradation. Topical application of Voxvoganan has a good safety profile and a low bioavailability. Voxvoganan demonstrates good activity agains

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Johan Isaksson, et al. A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95.
[2]. Louis D Saravolatz, et al. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug;56(8):4478-82.

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Voxvoganan

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