YB-0158|1144043-83-3|(Wnt pathway inhibitor 2)-陌孚医药/Medlife

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YB-0158 (Synonyms: Wnt pathway inhibitor 2)

目录号: PL13191 纯度: ≥99%

CAS No. :1144043-83-3

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中文名称	YB-0158
英文名称	YB-0158
英文别名	disodium;[4-[[(6S,9aS)-1-(benzylcarbamoyl)-8-(1H-indazol-7-ylmethyl)-4,7-dioxo-2-prop-2-enyl-3,6,9,9;YB-0158
Cas No.	1144043-83-3
分子式	C₃₂H₃₂N₇Na₂O₇P
分子量	703.59
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	YB-0158 (Wnt pathway inhibitor 2) 是一种反向转肽模拟物和一种有效的结直肠癌干细胞 (CSC) 靶向剂。YB-0158 破坏 Sam68-Src 相互作用并诱导结直肠癌细胞凋亡。YB-0158 具有抗癌活性。
生物活性	YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities.
性状	Solid
IC50 & Target[1][2]	Wnt signaling
体外研究(In Vitro)	YB-0158 (0.2 μM and 0.5 μM; 48 hours) significantly increases apoptosis in CRC cells as represented by activated Caspase-3/7 detection assays. YB-0158 (0.3 μM) similarly decreases CBP recruitment at the promoter of Wnt/beta-Catenin target genes LGR5 and MYC in HT29 cells, compared with DMSO control. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	YB-0158 displays an EC 50 (1.64 μM) in cultured MC38 cells. YB-0158 (100 mg/kg; IP; C57BL/6 mice bearing MC38 cells) shows no significant differences in primary tumor size in vivo treatments versus saline controls. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Masibag AN, Bergin CJ, Haebe JR, et al. Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 2021;24(12):103442.

溶解度数据	In Vitro: DMSO : 100 mg/mL (142.13 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic;adjust pH to 1 with 1M HCl) (insoluble)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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