FIDAS-3|1266684-01-8|-陌孚医药/Medlife

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FIDAS-3

目录号: PL13190 纯度: ≥99%

CAS No. :1266684-01-8

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中文名称	FIDAS-3
英文名称	FIDAS-3
英文别名	FIDAS-3;4-[2-(2,6-Difluorophenyl)ethenyl]-N,N-dimethylaniline;BDBM102424;NSC783761;Fluorinated N,N-Dialkylaminostilbenes 3;(E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline;trans-2,6-difluoro-4'-(N,N-dimethylamino)stilbene;4-[(E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethylaniline
Cas No.	1266684-01-8
分子式	C₁₆H₁₅F₂N
分子量	259.29
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	FIDAS-3 是一种二苯乙烯衍生物，也是一种强效的 Wnt 抑制剂，对甲硫氨酸腺苷转移酶 2A (MAT2A) 的 IC₅₀ 为 4.9 μM。FIDAS-3 与 S-腺苷甲硫氨酸 (SAM) 有效竞争 MAT2A 结合，并具有抗癌活性。
生物活性	FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC 50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities.
性状	Solid
IC50 & Target[1][2]	IC50: 4.9 μM (Methionine S-adenosyltransferase 2A (MAT2A))
体外研究(In Vitro)	FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. [2]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97.

溶解度数据	In Vitro: DMSO : 100 mg/mL (385.67 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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