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EMT inhibitor-1

目录号: PL11840 纯度: ≥99%

EMT inhibitor-1 是 Hippo，TGF-β 和 Wnt 信号通路的抑制剂，并拥有抗肿瘤活性。

CAS No. :1638526-21-2

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中文名称	EMT inhibitor-1
中文别名	4-((4-(3,4-二氯苯基)-1,2,5-噻二唑-3-基)氧基)丁-1-醇
英文名称	EMT inhibitor-1
英文别名	EMT inhibitor-1;4-((4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl)oxy)butan-1-ol;4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]butan-1-ol;4-{[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy}butan-1-ol;SB19125
Cas No.	1638526-21-2
分子式	C₁₂H₁₂Cl₂N₂O₂S
分子量	319.21
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	EMT inhibitor-1 是 Hippo，TGF-β 和 Wnt 信号通路的抑制剂，并拥有抗肿瘤活性。

产品详情

EMT inhibitor-1 是 Hippo，TGF-β 和 Wnt 信号通路的抑制剂，并拥有抗肿瘤活性。

生物活性

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

性状

Solid

IC50 & Target[1][2]

Hippo, TGF-β, Wnt.

体外研究(In Vitro)

EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide). has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (313.27 mM)配制储备液

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产品使用指南

Data Sheet

[1]. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

EMT inhibitor-1

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