Teplinovivint|1428064-91-8|-陌孚医药/Medlife

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Teplinovivint

目录号: PL13195 纯度: ≥99%

CAS No. :1428064-91-8

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中文名称	Teplinovivint
中文别名	N-(6-methoxypyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide
英文名称	Teplinovivint
英文别名	N-(6-methoxypyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide;Teplinovivint;6C8YA9VY55;Teplinovivint [INN];1H-Indazole-3-carboxamide, N-(6-methoxy-3-pyridinyl)-5-(5-(1-piperidinylmethyl)-3-pyridinyl)-;N-(6-Methoxypyridin-3-yl)-5-(5-piperidin-1 yl methyl)pyridin-3-yl)-1H-indazole-3-carboxamide;N-(6-methoxypyridin-3-yl)-5-[5-(piperidin-1-ylmethyl)pyridin-3-yl]-1H-indazole-3-carboxamide
Cas No.	1428064-91-8
分子式	C₂₅H₂₆N₆O₂
分子量	442.51
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	Teplinovivint 是一种有效的 wnt/β-catenin 信号通路抑制剂。Teplinovivint 具有抗炎活性，具有用于肌腱病研究的潜力。
生物活性	Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research.
性状	Solid
体外研究(In Vitro)	Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC50=152.9 nM). Teplinovivint inhibits SW480 cells (EC50=25 nM) and primary human mesenchymal stem cells (hMSCs; EC50=10.377 μM). Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC50 between 139-189 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Teplinovivint (compound 175; 10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model. Teplinovivint (1 mg/ml with 1% BA) has a T max of 1 hours in plasma. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Vishal DESHMUKH, et al. Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors. WO2018075858A1.

溶解度数据	In Vitro: DMSO : 83.33 mg/mL (188.31 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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