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UTL-5g

(Synonyms: GBL-5g)

目录号: PL11954 纯度: ≥98%

UTL-5g (GBL-5g) 是一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。

CAS No. :646530-37-2

商品编号	规格	价格	会员价
PL11954-5mg	5mg	¥531.00	请登录
PL11954-10mg	10mg	¥828.00	请登录
PL11954-25mg	25mg	¥1425.00	请登录
PL11954-50mg	50mg	¥2025.00	请登录
PL11954-100mg	100mg	¥2855.00	请登录
PL11954-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4420.00	请登录
PL11954-1 mL x 10 mM (in DMSO)		¥841.00	请登录

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中文名称	UTL-5g
英文名称	UTL-5g
英文别名	3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-;N-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-3-carboxamide;UTL-5g
Cas No.	646530-37-2
分子式	C₁₁H₈Cl₂N₂O₂
分子量	271.10
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	UTL-5g (GBL-5g) 是一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。

产品详情	UTL-5g (GBL-5g) 是一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。
生物活性	UTL-5g (GBL-5g), an anti-inflammatory TNF-α inhibitor, has chemoprotective and liver radioprotective effects. UTL-5g lowers hepatotoxicity, nephrotoxicity, and myelotoxicity induced by Cisplatin through TNF-α inhibition among other factors.
性状	Solid
体外研究(In Vitro)	RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 μM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation. UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Stephen Brown, et al. UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation [2]. Carruthers NJ, et al. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation. Eur J Pharmacol. 2017;8

溶解度数据	In Vitro: DMSO : 100 mg/mL (368.87 mM; Need ultrasonic)配制储备液

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[1]. Stephen Brown, et al. UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation
[2]. Carruthers NJ, et al. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation. Eur J Pharmacol. 2017;8

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

UTL-5g

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