KR-33493|1021497-97-1|-陌孚医药/Medlife

您当前的位置：

KR-33493

目录号: PL11933 纯度: ≥99%

CAS No. :1021497-97-1

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	KR-33493
中文别名	4-[[2-(4-溴苯基硫基)乙酰基]氨基]-1-苯乙基-1H-吡唑-3-羧酸;KR-33494
英文名称	KR-33493
英文别名	KR-33494;KR 33494;4-(2-(4-bromophenylthio)acetamido)-1-phenethyl-1H-pyrazole-3-carboxylic acid;KR-33493;NCH0QD81ZR;4-[[2-[(4-Bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid;BCP19823;4-((2-(4-Bromophenylsulfanyl)acetyl)amino)-1-phenethyl-1H-pyrazole-3-carboxylic acid;4-(2-((4-bromophenyl)thio)acetamido)-1-phenethyl-1H-pyrazole-3-carboxylic acid;4-[[2-(4-b;Unii-nch0QD81ZR
Cas No.	1021497-97-1
分子式	C₂₀H₁₈BrN₃O₃S
分子量	460.34
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	KR-33493 是一个有效的 Fas 介导细胞死亡 (FAF1) 的抑制剂。
生物活性	KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
性状	Solid
IC50 & Target[1][2]	Fas
体内研究(In Vivo)	Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUC last is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Jeong JW, et al. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinsons disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016 Nov;81:387-396.

溶解度数据	In Vitro: DMSO : ≥ 31 mg/mL (67.34 mM)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品