Lucatumumab|903512-50-5|(HCD122)-陌孚医药/Medlife

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Lucatumumab (Synonyms: HCD122)

目录号: PL11947 纯度: ≥95%

CAS No. :903512-50-5

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PL11947-1mg	1mg	¥3536.00	请登录
PL11947-5mg	5mg	¥8840.00	请登录
PL11947-10mg	10mg	¥14144.00	请登录
PL11947-50mg	50mg	询价	询价
PL11947-100mg	100mg	询价	询价

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中文名称	Lucatumumab
中文别名	LUCATUMUMAB ( 卢卡木单抗 );卢卡木单抗
英文名称	Lucatumumab
英文别名	Lucatumumab
Cas No.	903512-50-5
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Lucatumumab (HCD122) 是一种全人抗 CD40 拮抗剂单克隆抗体，可阻断 CD40/ CD40L 介导的信号通路。Lucatumumab 可有效介导抗体依赖性细胞介导的细胞毒性 (ADCC) 和肿瘤细胞清除，可用于顽固性淋巴瘤、慢性淋巴细胞白血病 (CLL) 和多发性骨髓瘤研究。

生物活性

Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research.

性状

Liquid

IC50 & Target[1][2]

CD40

体外研究(In Vitro)

Lucatumumab (0.001-10 μg/mL; 4 h; 37 ℃) inhibit B-cell chronic lymphocytic leukemia (B-CLL) growth by ADCC-mediated cell lysis, with the average maximal lysis of B-CLL cells of 49%.
Lucatumumab (0.1-10 μg/mL; 3 d) inhibits CD40L-induced signaling and viability of B-CLL cells.
Lucatumumab (10 μg/mL; 24 h) inhibits cytokine secretion by B-CLL cells.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Luqman M, et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood. 2008 Aug 1;112(3):711-20.
[2]. Drgona L, et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid or myeloid cells surface antigens [II]: CD22, CD30, CD33, CD38, CD40, SLAMF-7 and CCR4). Clin Microbiol Infect. 2018 Jun;24 Suppl 2:S83-S94.

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