SPD304 dihydrochloride|1049741-03-8|-陌孚医药/Medlife

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SPD304 dihydrochloride

目录号: PL11953 纯度: ≥99%

CAS No. :1049741-03-8

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中文名称	SPD304 dihydrochloride
英文名称	SPD304 dihydrochloride
英文别名	SPD304Hydrochloride;SPD304 dihydrochloride
Cas No.	1049741-03-8
分子式	C₃₂H₄₀Cl₂F₃N₃O₂
分子量	626.58
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	SPD304 dihydrochloride 是肿瘤坏死因子 α (TNF-α) 的选择性抑制剂，能够促进肿瘤坏死因子三聚体的分离，从而阻断其与受体间的相互作用。SPD304 体外抑制肿瘤坏死因子 α 和受体 1 间结合的 IC₅₀ 值为 22 µM。
生物活性	SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC 50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α.
性状	Solid
IC50 & Target[1][2]	IC50: 22 μM (TNFα).
体外研究(In Vitro)	SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p?RIP3 1.4?fold compared to GA alone, and promotes caspase 8 activation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	SPD304 cannot be used in vivo due to its high toxicity. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005. [2]. Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805. [3]. Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein int

溶解度数据	In Vitro: DMSO : 11.36 mg/mL (18.31 mM; ultrasonic and warming and heat to 60°C)配制储备液

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