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| 中文名称 |
Enfuvirtide acetate
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|---|---|
| 中文别名 |
恩夫韦肽乙酸酯;醋酸恩夫韦地
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| 英文名称 |
Enfuvirtide acetate
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| 英文别名 |
Enfuvirtide Acetate;Enfuvirtide acetate
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| Cas No. |
914454-00-5
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| 包装储存 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| 产品详情 |
Enfuvirtide (T20; DP178) acetate 是一种抗 HIV-1 融合的抑制肽。
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|---|---|
| 生物活性 |
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
HIV fusion
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| 体外研究(In Vitro) |
A cell-cell fusion assay reveals that the effective concentration for achieving 50% inhibition (IC50) of Enfuvirtide is 23 ± 6 nM. IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz, Indinavir, and Enfuvirtide) significantly inhibita the expression of HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3) also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz, Indinavir, and Enfuvirtide. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Enfuvirtide has a T 1/2 of 3.8 h. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| ClinicalTrial |
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| SequenceShortening |
Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2
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| Sequence |
Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
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| 参考文献 |
[1]. Figueira TN, et al. Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance. Sci Rep. 2017 Mar 30;7:45647.[2]. Cao P, et al. The improved efficacy of Sifuvirtide compared with Enfuvirtide might be related to its selectivity for the rigid biomembrane, as determined through surface plasmon resonance. PLoS One. 2017 Feb 16;12(2):e0171567.
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| 溶解度数据 |
In Vitro: DMSO : 100 mg/mL (21.97 mM; Need ultrasonic)H2O : 2 mg/mL (0.44 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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