Cefiderocol (S-649266) 是一种铁载体头孢菌素，对有氧革兰氏阴性细菌 (Gram-negative bacterial) 种类具有强效广谱的活性。

Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC 50 s of 2 μg/mL or less.

Solid

β-lactam

Cefiderocol (S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii . Cefiderocol has affinity mainly for PBP3 of Enterobacteriaceae and nonfermenting bacteria similar to that of GR20263. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli can cause 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

[1]. Ito A, et al. In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria. Antimicrob Agents Chemother. 2017 Dec 21;62(1).

In Vitro: DMSO : ≥ 125 mg/mL (166.18 mM)H₂O : 1.06 mg/mL (1.41 mM; Need ultrasonic)Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)