PAβN dihydrochloride|100929-99-5|(MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride)-陌孚医药/Medlife

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PAβN dihydrochloride (Synonyms: MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride)

目录号: PL12277 纯度: ≥99%

CAS No. :100929-99-5

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中文名称	PAβN dihydrochloride
中文别名	L-苯丙氨酰-N-2-萘基-L-精氨酰胺二盐酸盐;苯丙氨酸-精氨酸-Β-萘胺
英文名称	PAβN dihydrochloride
英文别名	L-Argininamide,L-phenylalanyl-N-2-naphthalenyl-, dihydrochloride (9CI);2-[(2-amino-3-phenylpropanoyl)amino]-5-(diaminomethylideneamino)-N-naphthalen-2-ylpentanamide,hydrochloride;H-Phe-Arg-βNA · 2 HCl;PHE-ARG BETA-NAPHTHYLAMIDE DIHYDROCHLORIDE;Phe-Arg-ßNA·2HCl;Phe-Arg-β-naphthylamide;2-(2-amino-3-phenylpropanamido)-5-carbamimidamido-N-(naphthalen-2-yl)pentanamide hydrochloride;MC-207,110 dihydrochloride;MC207110 dihydrochloride;Phe-Arg-β-naphthylamide dihydrochloride;H-Phe-Arg-bNA·2HCl;H-PHE-ARG-BETANA 2 HCL;PAβN (dihydrochloride);Phe-Arg beta-naphthylamide;phe-argbeta-naphthylamide2HCl;phe-arg β-naphthylamide dihydrochloride;phe-arg B-naphthylamide dihydrochloride;PAβN dihydrochloride
Cas No.	100929-99-5
分子式	C₂₅H₃₀N₆O₂^.HCl
分子量	483.01
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	PAβN dihydrochloride (MC-207110 dihydrochloride)是外排泵的抑制剂。
生物活性	PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
性状	Solid
体外研究(In Vitro)	PAβN increases the susceptibilities of the three pump-overexpressing mutants of P. aeruginosa to levofloxacin 64-fold. PAβN also potentiates the activity of levofloxacin against strain PAM2391 containing plasmid pAGH97 with the mexXY genes and against wild-type strain PAM1020. PAβN has an effect on susceptibilities to other antibiotics that are substrates of efflux pumps. PAβN increases levels of accumulation of efflux pump substrates inside the cell. It enhances the activity of levofloxacin against clinical isolates of P. aeruginosa. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-r
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16. [2]. Kurin?i? M, et al. Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. Microb Drug Resist. 2012 Oct;18(5):492-501.

溶解度数据	In Vitro: DMSO : 83.33 mg/mL (160.41 mM; Need ultrasonic)H₂O : 14.29 mg/mL (27.51 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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