Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
详情描述
Peceleganan acetate 是一种人工抗菌天蚕素 A (1-10) × 蜂毒素 B (3-18) 杂化 (10+16) 肽类似物。Peceleganan acetate 抑制伤口感染。
产品详情
Peceleganan acetate 是一种人工抗菌天蚕素 A (1-10) × 蜂毒素 B (3-18) 杂化 (10+16) 肽类似物。Peceleganan acetate 抑制伤口感染。
生物活性
Peceleganan acetate is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan acetate inhibits wound infection.
性状
Solid
体外研究(In Vitro)
Peceleganan (24 h) acetate 具有抗菌活性,对 E. coli ATCC 25922、 S. pneumonia ATCC 49619、 K. pneumonia ATCC 700603、 S. aureus ATCC 25923、 S. epidermidis ATCC 12228 和 P. aeruginosa ATCC 27853 的 MIC 值分别为 2、2、4、4、4 和 8 μM。 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Peceleganan (0.4 and 0.75 mg/mL for 100 μL; transdermal; twice daily for 3 days) acetate 在小鼠感染模型中抑制 Staphylococcus aureus。 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: ICR m
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
[1]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical.[2]. Feng Q, et al. Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):197-204.
溶解度数据
In Vitro: H2O : 50 mg/mL (16.70 mM; Need ultrasonic)配制储备液
[1]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical.[2]. Feng Q, et al. Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):197-204.