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Cefmenoxime hydrochloride

(Synonyms: 盐酸头孢甲肟; SCE-1365 hydrochloride)

目录号: PL12180 纯度: ≥98%

Cefmenoxime (SCE-1365) hydrochloride 是一种新型半合成头孢菌素类抗生素。头孢甲肟对多种革兰氏阳性和革兰氏阴性细菌具有抗菌活性。

CAS No. :75738-58-8

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中文名称	Cefmenoxime hydrochloride
中文别名	盐酸头孢甲肟;(6R,7R)-7-[2-(2-氨基-4-噻唑基)(甲氧亚氨基)乙酰氨基]-3-[[(1-甲基-1H-四唑-5-基)-硫]甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸盐酸盐;盐酸头孢甲肟 GMP;那高利特盐酸盐;头孢甲肟;头孢甲肟盐酸盐;盐酸氨噻唑肟;盐酸头孢甲肟 USP标准品;盐酸头孢甲肟(非无菌)
英文名称	Cefmenoxime hydrochloride
英文别名	Cefmenoxime hydrochloride;8-[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino-4-[(1-methyltetrazol-5-yl)sulfanylmethyl]-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid hydrochloride (2:1);Apacef;Apatef;Cefmenoxime hemihydrochloride;CEFOTETAN;Cefotetan (500 mg);Cefotetan acid;CEFOTETAN SODIUM;Ceftenon;Cepan Darvilen;SCE-1365 hemihydrochloride;Yamatetan;Cefmenoxime HCl;Cefmax;NON736D32W;Abbott 50192 (HCl);AB 50912 hemihydrochloride;SCE 1365 hydrochloride;Bestcall (TN);(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid 7(sup 2)-(Z)-(O-methyloxime), hydrochloride (2:1);Cefmenoxime hydrochloride [USAN:USP:JAN];NCGC00
Cas No.	75738-58-8
分子式	C₃₂H₃₅ClN₁₈O₁₀S₆
分子量	1059.58
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Cefmenoxime (SCE-1365) hydrochloride 是一种新型半合成头孢菌素类抗生素。头孢甲肟对多种革兰氏阳性和革兰氏阴性细菌具有抗菌活性。

产品详情	Cefmenoxime (SCE-1365) hydrochloride 是一种新型半合成头孢菌素类抗生素。头孢甲肟对多种革兰氏阳性和革兰氏阴性细菌具有抗菌活性。
生物活性	Cefmenoxime (SCE-1365) hydrochloride is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria.
性状	Solid
IC50 & Target[1][2]	β-lactam
体外研究(In Vitro)	Cefmenoxime (SCE-1365) hydrochloride inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae . Cefmenoxime (SCE-1365) hydrochloride inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes , respectively, and 2 μg/mL for S. aureus . Cefmenoxime (SCE-1365) hydrochloride against Haemophilus influenzae , Neisseria gonorrhoeae , and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Cefmenoxime (SCE-1365) hydrochloride (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Stamm JM, et, al. Antimicrobial activity of cefmenoxime (SCE-1365). Antimicrob Agents Chemother. 1981 Mar;19(3):454-60. [2]. Tatara O, et, al. Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):167-71.

溶解度数据	In Vitro: DMSO : 65 mg/mL (122.69 mM; Need ultrasonic and warming)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

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[1]. Stamm JM, et, al. Antimicrobial activity of cefmenoxime (SCE-1365). Antimicrob Agents Chemother. 1981 Mar;19(3):454-60.
[2]. Tatara O, et, al. Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):167-71.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Cefmenoxime hydrochloride

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