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SU0268

目录号: PL12227 纯度: ≥99%

SU0268 是有效的、特异性的 8-8-氧鸟嘌呤 DNA 糖基化酶1 (OGG1) 的抑制剂。SU0268 可调控铜绿假单胞杆菌感染的免疫反应。

CAS No. :2210228-45-6

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PL12227-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2298.00	请登录
PL12227-1 mL x 10 mM (in DMSO)		¥890.00	请登录

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中文名称	SU0268
中文别名	4'-(N-(1-(环丙烷羰基)-1,2,3,4-四氢喹啉-7-基)氨磺酰基)-[1,1'-联苯]-3-甲酰胺
英文名称	SU0268
英文别名	4'-[[[1-(Cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl][1,1'-biphenyl]-3-carboxamide;SU0268;[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-;NSC804557;SU 0268;BS167477;4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;3-[4-[[1-(cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-7-yl]sulfamoyl]phenyl]benzamide;E85046
Cas No.	2210228-45-6
分子式	C₂₆H₂₅N₃O₄S
分子量	475.56
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	SU0268 是有效的、特异性的 8-8-氧鸟嘌呤 DNA 糖基化酶1 (OGG1) 的抑制剂。SU0268 可调控铜绿假单胞杆菌感染的免疫反应。

产品详情	SU0268 是有效的、特异性的 8-8-氧鸟嘌呤 DNA 糖基化酶1 (OGG1) 的抑制剂。SU0268 可调控铜绿假单胞杆菌感染的免疫反应。
生物活性	SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
性状	Solid
体外研究(In Vitro)	MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), than their control shGFP counterparts. SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells. SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate. SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Ling Zhang, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848. [2]. Yu-Ki Tahara, et al. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. J Am Chem Soc. 2018 Feb 14;140(6):2105-2114. [3]. Shugang Qin, et al. Small-Molecule Inhibi

溶解度数据	In Vitro: DMSO : 100 mg/mL (210.28 mM; Need ultrasonic)配制储备液

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[1]. Ling Zhang, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848.
[2]. Yu-Ki Tahara, et al. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. J Am Chem Soc. 2018 Feb 14;140(6):2105-2114.
[3]. Shugang Qin, et al. Small-Molecule Inhibi

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

SU0268

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