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Acriflavine

(Synonyms: 吖啶黄; Acriflavinium chloride 3,6-Acridinediamine mix)

目录号: PL12251 纯度: ≥98%

Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。

CAS No. :8048-52-0

商品编号	规格	价格	会员价
PL12251-100mg	100mg	¥358.00	请登录
PL12251-200mg	200mg	询价	询价
PL12251-500mg	500mg	¥847.00	请登录
PL12251-10mM*1mLinWater	10mM*1mLinWater	¥1060.00	请登录

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中文名称	Acriflavine
中文别名	吖啶黄;吖啶黄素;吖黄素;吖啶黃素;吖啶黄素(3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合物);吖啶素;丫啶黄素;吖啶黄标准品;吖啶黄,BS;3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶混合物;吖啶黄 (3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合物);吖黄素 (3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合物)
英文名称	Acriflavine
英文别名	Acriflavine;2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE;ACRIFLAVINE BASE;ACRIFLAVINE NEUTRAL;3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE;EUFLAVIN;EUFLAVINE;CI 46000;Acriflavine (mixture of 3,6-Diamino-10-methylacridinium Chloride and 3,6-Diaminoacridine);ACRIFLAVINE (FOR BIOCHEMISTRY), (C.I. 46000);ACRIFLAVINE NEUTRAL C.I. NO. 46000 ULTRA PURE GRADE;Acriflavine(Neutral);angiflan;diacrid;flavine;flavipin;flavisept;gonacin;isravin;3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine (proflavine);Trypaflavine Neutral;Euflavine;3,6-Diamino-10-methylacridinium chloride
Cas No.	8048-52-0
分子式	C₁₄H₁₄N₃^.Cl^.C₁₃H₁₁N₃
分子量	468.99
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。

产品详情

Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。

生物活性

Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.

性状

Solid

体外研究(In Vitro)

Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.
[2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588.

溶解度数据	In Vitro: H₂O : ≥ 25 mg/mL (96.25 mM)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Acriflavine

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